STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF SELECTED 
CHEMICALS IN LABORATORY ANIMALS VIA INHALATION FOR THE NATIONAL TOXICOLOGY 
PROGRAM - 1-BROMOPOPANE, COBALT METAL, DIETHYLAMINE, AND TRIETHYLAMINE

Release Date:  June 12, 2001

NOTICE:  NOT-ES-01-006

RFP NIH-ES-01-13

National Institute of Environmental Health Sciences

The NIEHS is soliciting offers for a contract to evaluate the
toxicologic and carcinogenic potential of selected chemicals to which
humans are exposed in the workplace or at home via inhalation.  This
project includes 14-day, 90-day, and 2-year studies of 1-Bromopropane,
Cobalt metal, Diethylamine, and Triethylamine.  Multiple studies shall
be conducted concurrently.  The base contract shall consist of Phase 1
for all four chemicals to include those work activities associated
with identity and purity determination of the bulk chemical,
development of generation and monitoring methods, health and safety
concerns, and the conduct of the 14-day study.  Upon successful
completion of Phase 1, the Government may unilaterally exercise
options for the conduct of 90-day studies specified as Phase 2.  Upon
successful completion of Phase 2, the Government may unilaterally
exercise options for the conduct of 2-year studies specified as Phase
3.  These studies shall be conducted according to the Specifications
for the Conduct of Studies to Evaluate the Toxic and Carcinogenic
Potential of Chemical, Biological and Physical Agents in Laboratory
Animals for the National Toxicology Program dated September 2000.
Offerors shall have a working laboratory conducting studies by the
required route of administration in place by the date of proposal
submission.  The Principal Investigator, Engineer/Exposure Specialist,
Toxicologist, Chemist, Veterinarian, Health and Safety Officer and
Quality Assurance Unit Officer shall be employees of the contract
laboratory (i.e., not consultants or subcontractors).  The daily
interaction and constant coordination of efforts needed amongst these
discipline areas throughout the in-life portion of the studies makes
it critical that they be physically and organizationally together.
Award of one cost-reimbursement, completion type contract on March 29,
2002 on an open competition basis is contemplated as a result of this
solicitation.  The estimated level of effort is 13,405 labor hours for
the base contract and 135,260 labor hours for all options.  The
estimated period of performance is approximately nine months for the
base contract and  four years seven months if all options are
exercised.  Interested organizations should telefax a request for RFP
NIH-ES-01-13 to the attention of Ms. Melissa Pittman, Procurement
Technician at  (919) 541-2712 or send an e-mail request to
pittman@niehs.nih.gov.  The electronic version of the CBD synopsis
is available on the Internet at:
http://www.niehs.nih.gov/dert/rcb/rfp.htm.  An electronic copy of the
RFP (without the NTP Specifications) will be posted to this site on or
about June 18, 2001.    All responsible sources may submit a proposal
which shall be considered by the Agency.  Expected release date of the
RFP is June 18, 2001 with proposals due August 10, 2001.


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