Release Date:  March 20, 2001

NOTICE:  NOT-ES-01-004

RFP NIH-ES-01-08

National Institute of Environmental Health Sciences

The NIEHS is soliciting offers for a contract to evaluate the
toxicologic and carcinogenic potential of selected chemicals via dosed
feed, dermal, or gavage routes of administration.  This project
includes 2-year studies of Cresol, 1,2-Dibromo-2,4-Dicyanobutane,
Tetrachloroazobenzene and 14-day, 90-day, and 2-year studies of
Ginseng and Kava Kava Extract.   Multiple studies shall be conducted
concurrently.  The base contract shall consist of Phase 1 for all five
chemicals to include those work activities associated with the
determination of bulk chemical purity and identity, and validation of
dose formulation/analysis methods, and any health and safety concerns.
Upon successful completion of Phase 1, the Government may unilaterally
exercise options for the conduct of 14-day, 21-day, 90-day, or 2-year
studies specified as Phases 2 through 4.  These studies shall be
conducted according to the Specifications for the Conduct of Studies
to Evaluate the Toxic and Carcinogenic Potential of Chemical,
Biological and Physical Agents in Laboratory Animals for the National
Toxicology Program dated September 2000.  Offerors shall have a
working laboratory involved in conducting studies by the required
routes of administration  in place by the date of proposal submission.
The Principal Investigator, Toxicologist, Chemist, Veterinarian,
Health and Safety Officer and Quality Assurance Unit Officer shall be
employees of the contract laboratory (i.e., not consultants or
subcontractors).  The daily interaction and constant coordination of
efforts needed amongst these discipline areas throughout the in-life
portion of the studies makes it critical that they be physically and
organizationally together.  Award of one cost-reimbursement, completion
type contract on December 28, 2001 on an open competition basis is
contemplated as a result of this solicitation.  The estimated level of
effort is 1,505 labor hours for the base contract and 116,160 labor
hours for all options.  The estimated period of performance is
approximately nine months for the base contract and four years eight
months if all options are exercised.  Interested organizations should
request either a streamlined or full RFP package.  If no selection is
made, a streamlined version of the RFP will be provided, which will
include only the Statement of Work, deliverables and reporting
requirements, special requirements, mandatory qualifications, and
technical evaluation criteria.  After examination of these documents,
any organization interested in responding to this RFP must request the
entire RFP by written, telephonic ((919) 541-0416), telefax request
((919) 541-2712), or e-mail request (  The electronic 
version of the CBD synopsis and the RFP (which will be available on or about 
April 4, 2001 without the NTP specifications) is available on the Internet at:   All responsible
sources may submit a proposal which shall be considered by the Agency.
Expected release date of the RFP is April 4, 2001 with proposals due
June 04, 2001. 

Requests should reference RFP NIH-ES-01-08 and should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN:  Marilyn B. Whaley, Contracting Officer
79 T.W. Alexander Drive, 4401 Building
P. O. Box 12874
Research Triangle Park, NC  27709

Melissa M. Pittman
National Institute of Environmental Health Sciences
Research Contracts Branch
P.O. Box 12874
Research Triangle Park, NC  27709
919-541-2712 (FAX)

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