COMPLEX CHEMICAL MIXTURES INTERAGENCY ANNOUNCEMENT 2000 SCIENCE TO ACHIEVE 
RESULTS (STAR) PROGRAM

Release Date:  April 24, 2000

Closing Date:  July 10, 2000

NOTICE:  ES-00-003

U.S. Environmental Protection Agency
National Institute of Environmental Health Sciences
National Institute for Occupational Safety and Health

This announcement is a collaborative effort between the U.S. Environmental 
Protection Agency and the Department of Health and Human Services (National 
Institute of Environmental Health Sciences and National Institute for 
Occupational Safety and Health).  The purpose of this announcement is to 
stimulate innovative experimental approaches and computational, statistical, 
or predictive strategies for assessing the impact of chemical mixtures that 
focus on the mechanistic basis for chemical interactions and related health 
effects.

The National Institute of Environmental Health Sciences (NIEHS) supports 
research that examines human health consequences of exposure to physical and 
chemical toxicants in the environment as well as the underlying mechanisms 
involved in environmentally related disease
and dysfunction.  NIEHS is interested in understanding what mixtures of 
chemicals the public is exposed to as well as the mechanisms involved in the 
interaction of these mixtures and subsequent health effects.  The development 
of predictive computational and statistical tools that incorporates 
mechanistic information and can be applied to risk assessment is of particular 
interest.    

The research needs identified in this announcement relevant to the National 
Institute for Occupational Safety and Health (NIOSH) are consistent with the 
National Occupational Research Agenda (NORA) developed by NIOSH and partners 
in the public and private sectors to provide a framework to guide occupational 
safety and health research into the next decade.  There are 21 research 
priority areas identified in NORA, however, the area with specific relevance 
to this announcement is "Mixed Exposures."  Exposures to combinations of 
chemical or physical agents is common in many occupations, but knowledge about 
the potential health effects of such exposures is limited.  Thus, NIOSH is 
interested in studies that identify synergistic effects of multiple exposure, 
improve characterization of worker exposures to mixtures, or improve 
laboratory and statistical analysis methods.

Information about this RFA can be obtained on the US EPA homepage at: 
http://es.epa.gov/ncerqa/rfa/mixtures00.html.  Applications should be sent to 
the U.S. EPA. no later than 4:00 P.M. ET on July 10, 2000.

INQUIRIES

For additional information about this RFA, contact:

Dr. Claudia Thompson, Ph.D.
Scientific Program Administrator
Chemical Exposures and Molecular Biology Branch
Office of Program Development
National Institute of Environmental Health Sciences
P.O. Box 12233, MD EC-21
Research Triangle Park, NC 27709
Telephone: (919) 541-4638
Fax: (919) 316-4606
Email: [email protected]

or

Michael Galvin, Jr., Ph.D. 
Research Grants Program
National Institute for Occupational Safety and Health
1600 Clifton Road, NE
Building 1, Room 3043, MS D30
Atlanta, GA 30333
Telephone: (404) 639-1533 
Fax: (404) 639-4616
Email: [email protected]   

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