January 5, 2023
PAR-22-181 - NCCIH, NEI, NIAAA, NIDA, NIMH, NINR, and NINDS Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)
NOT-EB-22-014 - Notice of NIBIB’s Withdrawal form Participation in RFA-HG-21-041 New Investigators to Promote Workforce Diversity in Genomics, Bioinformatics, or Bioengineering and Biomedical Imaging Research (R01 Clinical Trial Optional).
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
The purpose of this Notice is to inform potential applicants of the National Institute of Biomedical Imaging and Bioengineering’s (NIBIB) participation, starting with the May 05, 2023 receipt date, in the funding opportunity announcement (FOA) PAR-22-181, NCCIH, NEI, NIAAA, NIDA, NIMH, NINR, and NINDS Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional).
The following sections of PAR-22-181 have been modified to reflect the NIBIB's participation in this FOA:
Part 1. Overview Information
Components of Participating Organizations
Currently Reads:
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Institute of Nursing Research (NINR)
National Center of Complementary and Intergrative Health (NCCIH)
National Eye Institute (NEI)
National Institute on Alchohol Abuse and Alcoholism (NIAAA)
Modified to Read (changes shown in bold italics):
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Institute of Nursing Research (NINR)
National Center of Complementary and Intergrative Health (NCCIH)
National Eye Institute (NEI)
National Institute on Alchohol Abuse and Alcoholism (NIAAA)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Funding Opportunity Title
Currently Reads:
Funding Opportunity Title NCCIH, NEI, NIAAA, NIDA, NIMH, NINR, and NINDS Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)
Revised to Read:
Funding Opportunity Title Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)
Assistance Listing Number(s)
Currently Reads:
93.853, 93.279, 93.242, 93.361, 93.213, 93.273, 93.867
Modified to Read (changes shown in bold italics):
93.853, 93.279, 93.242, 93.361, 93.867, 93.286
Section I. Funding Opportunity Description
Specific Areas of Research Interest:
Currently Reads:
NIDA
NIDA will support applications that address or seek fundamental knowledge related to addiction sciences, including, but not limited to: cellular and molecular neuroscience, neuroimaging, genetics, medication and treatment development, development of new and improved strategies to prevent substance use and its consequences, neuroimmune signaling, neuropathology in brain systems, cognitive processes, population neuroscience, HIV and drugs of abuse (including basic discovery science research as well as applied research on delivery of HIV and substance use prevention and treatment services to persons who use drugs), medication development, epidemiology, identifying the biological, environmental, behavioral, and social causes and consequences of substance use and addiction across the lifespan, and implementation science, including secondary data analysis. In all these and related areas of addiction sciences research, NIDA encourages an emphasis on understanding and addressing health disparities which are experienced by vulnerable populations. Only applications that fall within the scientific mission of NIDA will be considered for funding (https://nida.nih.gov/about-nida/strategic-plan/directors-message).
NIMH
The mission of the National Institute of Mental Health (NIMH) is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. NIMH supports research on topics that include basic neuroscience and behavioral science, and translational application of brain and behavior relationships in healthy and diseased states. Mental disorders may be defined according to existing diagnostic criteria or along dimensions of neurobehavioral functioning according to the NIMH Research Domain Criteria (RDoC) framework. If existing diagnostic criteria are to be used, investigators should include plans for addressing heterogeneity within the diagnostic category or categories. Applications considered for funding by the NIMH must fall within the areas of priority detailed in the NIMH Strategic Plan and the NIMH Strategic Research Priorities. It is recommended that investigators contact NIMH Scientific/Research staff well in advance of submitting applications to discuss the match to NIMH priorities. NIMH supports mechanistic clinical trials that focus on biomarker studies that may provide information about physiological function, target engagement of therapeutics, and/or the impact of therapeutic responses. These types of studies do not have as a primary aim to establish the efficacy or effectiveness of the intervention.
NIMH considers two major categories of mechanistic trials (though there may be others):
See the Consolidated Notice on NIMH Clinical Trials Policies, NOT-MH-20-105, for a summary of NIMH’s polices on support for mechanistic clinical trials.
NINDS
NINDS will support applications that address or seek fundamental knowledge about the brain and nervous system by supporting and conducting research on the healthy and diseased brain, spinal cord, and peripheral nerves and to use that knowledge to reduce the burden of neurological disease. NINDS supports basic, translational, and clinical research. NINDS also encourages activities focused on understanding and addressing disparities in neurologic health, healthcare, and health outcomes in disparate populations, including racial and ethnic minorities, the geographically disadvantaged, sex and gender minorities, and others who have been historically underserved, marginalized, and adversely affected by persistent inequality and socioeconomic disadvantage.
Only applications that fall within the scientific mission of the NINDS will be considered for funding (https://www.ninds.nih.gov/About-NINDS/Who-We-Are/Mission) and the NINDS Strategic Plan (https://www.ninds.nih.gov/About-NINDS/Strategic-Plans-Evaluations/Strategic-Plans/NINDS-Strategic-Plan-and-Priorities/Neuroscience-Research).
NINR
The National Institute of Nursing Research (NINR) supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Only applications that fall within these areas as detailed in the NINR 2022 2026 Strategic Plan will be considered. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses work, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest.
NIAAA
NIAAA will support applications that seek fundamental knowledge about the effecrts of alcohol on health and well being, and will apply that knowledge to improve diagnosis, prevention and treatment of alcohol related problems including alcohol use disorder, across the lifespan. NIAAA supports basic, translational and clinical research. Topics of interest include but are not limited to genetics, neuroscience, epidemiology, prevention and treatment of alcohol use disorder and alcohol related health conditions. NIAAAA also encourages activities focused on understanding and addressing disparities in the impact of alcohol use on health, heatlhcare accessand health outcomes in disparate popupulations. This includes racial and ethinc minorties, the geographically disadvantaged, sex and gender minorities and others who have been historically underserved, marginalized and adversely affected by prepsistent inequality and socioeconomic disadvantage.
NCCIH
NCCIH supports research regarding the use of complementary and integrative health approaches including natural products, mind and body interventions, and multicomponent interventions focused on whole person health. NCCIH is also interested in research studying mind and body approaches to manage stress, mild anxiety, or depression, or pain, and to improve adherence to treatment and prevention regimens to promote health outcomes. Natural products include botanicals, pre/probiotics, and products marketed as dietary supplements. Mind and body approaches include various meditation approaches (e.g., mindfulness), hypnosis or guided imagery, meditative movement approaches (e.g., yoga, tai chi, qi-gong), body-based approaches (e.g., spinal manipulation, massage, mobilization, acupuncture), a combination of these approaches (e.g., meditation and yoga, such as in mindfulness-based stress reduction MBSR), or complex interventions including music and art therapy. Research on whole person health includes multicomponent interventions designed to improve health in multiple interconnected domains: biological (including multiple organs and systems), behavioral, social, and environmental. NCCIH will not accept single-site or multi-site efficacy or effectiveness research through this FOA (please see NCCIH Clinical Trial Funding Opportunities instead). Applicants are strongly encouraged to discuss their plans with NCCIH Scientific/Research contact and to consult the NCCIH Strategic Plan to ensure their application addresses NCCIH scientific priorities prior to developing and submitting an application.
For applications proposing a clinical trial, note the following definitions and restrictions for this funding announcement:
Applicants are strongly advised to consult with the appropriate IC Scientific/Research staff prior to submitting an application with human subjects to determine the appropriate funding opportunity.
Per NOT-OD-16-011, the NIH expects applicants to apply rigor in designing and performing scientific research according to the NIH Principles and Guidelines for Reporting Preclinical Research.
NEI
The mission of the National Eye Institute (NEI) is to eliminate vision loss and improve quality of life through vision research. The NEI has framed its current strategic plan around this mission which addresses multiple opportunities as challenges in the vision field.
NEI will support applications that address or seek fundamental knowledge related to vision sciences, including, but not limited to: cellular and molecular neuroscience, imaging, genetics, development, basic/translational research on vision including how the visual system works from the eyes to the brain in health and disease. The overarching goal is to reduce visual impairment and blindness and thus resulting in an improvement in the quality of life for people of all ages. In all these areas and related areas of vision sciences research, NEI encourages an emphasis on understanding and addressing health disparities that are experienced by vulnerable populations.
For this funding opportunity, only the following trials will be supported by NEI.
Clinical trials that seek to answer specific questions about safety, tolerability, clinical efficacy, effectiveness, clinical management, and/or implementation of pharmacologic, biologic, surgical, or device (invasive or non-invasive) interventions, preventive, therapeutic, and services interventions will not be supported under this FOA. Please refer to https://www.nei.nih.gov/grants-and-training/funding-opportunities to find the appropriate NIH or NEI-specific FOA for such clinical trials.
Applications considered for funding by the NEI must fall within the areas of emphasis detailed in the NEI Strategic Plan. (NEI Strategic Plan: Vision for the Future (PDF 22.5 MB)
Modified to Read (changes shown in bold italics):
NIDA
NIDA will support applications that address or seek fundamental knowledge related to addiction sciences, including, but not limited to: cellular and molecular neuroscience, neuroimaging, genetics, medication and treatment development, development of new and improved strategies to prevent substance use and its consequences, neuroimmune signaling, neuropathology in brain systems, cognitive processes, population neuroscience, HIV and drugs of abuse (including basic discovery science research as well as applied research on delivery of HIV and substance use prevention and treatment services to persons who use drugs), medication development, epidemiology, identifying the biological, environmental, behavioral, and social causes and consequences of substance use and addiction across the lifespan, and implementation science, including secondary data analysis. In all these and related areas of addiction sciences research, NIDA encourages an emphasis on understanding and addressing health disparities which are experienced by vulnerable populations. Only applications that fall within the scientific mission of NIDA will be considered for funding (https://nida.nih.gov/about-nida/strategic-plan/directors-message).
NIMH
The mission of the National Institute of Mental Health (NIMH) is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. NIMH supports research on topics that include basic neuroscience and behavioral science, and translational application of brain and behavior relationships in healthy and diseased states. Mental disorders may be defined according to existing diagnostic criteria or along dimensions of neurobehavioral functioning according to the NIMH Research Domain Criteria (RDoC) framework. If existing diagnostic criteria are to be used, investigators should include plans for addressing heterogeneity within the diagnostic category or categories. Applications considered for funding by the NIMH must fall within the areas of priority detailed in the NIMH Strategic Plan and the NIMH Strategic Research Priorities. It is recommended that investigators contact NIMH Scientific/Research staff well in advance of submitting applications to discuss the match to NIMH priorities. NIMH supports mechanistic clinical trials that focus on biomarker studies that may provide information about physiological function, target engagement of therapeutics, and/or the impact of therapeutic responses. These types of studies do not have as a primary aim to establish the efficacy or effectiveness of the intervention.
NIMH considers two major categories of mechanistic trials (though there may be others):
See the Consolidated Notice on NIMH Clinical Trials Policies, NOT-MH-20-105, for a summary of NIMH’s polices on support for mechanistic clinical trials.
NINDS
NINDS will support applications that address or seek fundamental knowledge about the brain and nervous system by supporting and conducting research on the healthy and diseased brain, spinal cord, and peripheral nerves and to use that knowledge to reduce the burden of neurological disease. NINDS supports basic, translational, and clinical research. NINDS also encourages activities focused on understanding and addressing disparities in neurologic health, healthcare, and health outcomes in disparate populations, including racial and ethnic minorities, the geographically disadvantaged, sex and gender minorities, and others who have been historically underserved, marginalized, and adversely affected by persistent inequality and socioeconomic disadvantage.
Only applications that fall within the scientific mission of the NINDS will be considered for funding (https://www.ninds.nih.gov/About-NINDS/Who-We-Are/Mission) and the NINDS Strategic Plan (https://www.ninds.nih.gov/About-NINDS/Strategic-Plans-Evaluations/Strategic-Plans/NINDS-Strategic-Plan-and-Priorities/Neuroscience-Research).
NINR
The National Institute of Nursing Research (NINR) supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Only applications that fall within these areas as detailed in the NINR 2022 2026 Strategic Plan will be considered. Drawing on the strengths of nursing’s holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses work, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest.
NIAAA
NIAAA will support applications that seek fundamental knowledge about the effecrts of alcohol on health and well being, and will apply that knowledge to improve diagnosis, prevention and treatment of alcohol related problems including alcohol use disorder, across the lifespan. NIAAA supports basic, translational and clinical research. Topics of interest include but are not limited to genetics, neuroscience, epidemiology, prevention and treatment of alcohol use disorder and alcohol related health conditions. NIAAAA also encourages activities focused on understanding and addressing disparities in the impact of alcohol use on health, heatlhcare accessand health outcomes in disparate popupulations. This includes racial and ethinc minorties, the geographically disadvantaged, sex and gender minorities and others who have been historically underserved, marginalized and adversely affected by prepsistent inequality and socioeconomic disadvantage.
NCCIH
NCCIH supports research regarding the use of complementary and integrative health approaches including natural products, mind and body interventions, and multicomponent interventions focused on whole person health. NCCIH is also interested in research studying mind and body approaches to manage stress, mild anxiety, or depression, or pain, and to improve adherence to treatment and prevention regimens to promote health outcomes. Natural products include botanicals, pre/probiotics, and products marketed as dietary supplements. Mind and body approaches include various meditation approaches (e.g., mindfulness), hypnosis or guided imagery, meditative movement approaches (e.g., yoga, tai chi, qi-gong), body-based approaches (e.g., spinal manipulation, massage, mobilization, acupuncture), a combination of these approaches (e.g., meditation and yoga, such as in mindfulness-based stress reduction MBSR), or complex interventions including music and art therapy. Research on whole person health includes multicomponent interventions designed to improve health in multiple interconnected domains: biological (including multiple organs and systems), behavioral, social, and environmental. NCCIH will not accept single-site or multi-site efficacy or effectiveness research through this FOA (please see NCCIH Clinical Trial Funding Opportunities instead). Applicants are strongly encouraged to discuss their plans with NCCIH Scientific/Research contact and to consult the NCCIH Strategic Plan to ensure their application addresses NCCIH scientific priorities prior to developing and submitting an application.
For applications proposing a clinical trial, note the following definitions and restrictions for this funding announcement:
Applicants are strongly advised to consult with the appropriate IC Scientific/Research staff prior to submitting an application with human subjects to determine the appropriate funding opportunity.
Per NOT-OD-16-011, the NIH expects applicants to apply rigor in designing and performing scientific research according to the NIH Principles and Guidelines for Reporting Preclinical Research.
NEI
The mission of the National Eye Institute (NEI) is to eliminate vision loss and improve quality of life through vision research. The NEI has framed its current strategic plan around this mission which addresses multiple opportunities as challenges in the vision field.
NEI will support applications that address or seek fundamental knowledge related to vision sciences, including, but not limited to: cellular and molecular neuroscience, imaging, genetics, development, basic/translational research on vision including how the visual system works from the eyes to the brain in health and disease. The overarching goal is to reduce visual impairment and blindness and thus resulting in an improvement in the quality of life for people of all ages. In all these areas and related areas of vision sciences research, NEI encourages an emphasis on understanding and addressing health disparities that are experienced by vulnerable populations.
For this funding opportunity, only the following trials will be supported by NEI.
Clinical trials that seek to answer specific questions about safety, tolerability, clinical efficacy, effectiveness, clinical management, and/or implementation of pharmacologic, biologic, surgical, or device (invasive or non-invasive) interventions, preventive, therapeutic, and services interventions will not be supported under this FOA. Please refer to https://www.nei.nih.gov/grants-and-training/funding-opportunities to find the appropriate NIH or NEI-specific FOA for such clinical trials.
Applications considered for funding by the NEI must fall within the areas of emphasis detailed in the NEI Strategic Plan. (NEI Strategic Plan: Vision for the Future (PDF 22.5 MB)
NIBIB
NIBIB interests include the development and integration of advanced bioengineering, sensing, imaging, and computational technologies for the improvement of human health and medical care. An application is not within the NIBIB mission if its principal focus is the development of a technology with the goal of understanding basic biological function or pathological mechanisms. Additionally, NIBIB only supports projects developing platform technologies that are applicable to a broad spectrum of disorders and diseases. However, applicants may propose research that utilizes only a single tissue, organ, or physiological condition as a model system to facilitate the development of what is expected to be a more broadly applicable enabling technology. Potential applicants are encouraged to contact the appropriate Program Director in their scientific program area of interest (https://www.nibib.nih.gov/research-funding) to determine if their research fits within the NIBIB mission.
For applications proposing clinical trials, NIBIB funding of clinical trials will be in accordance with NOT-EB-21-005 NIBIB Guidance for Support of Clinical Trial Applications." Briefly, NIBIB will only support mission-focused early-stage clinical trial applications, i.e., feasibility, Phase I, first-in-human, safety, or other small clinical trials, that inform early-stage technology development. NIBIB will not support applications proposing pivotal, Phase II, III, IV, or trials in which the primary outcome is efficacy, effectiveness, or a post-market concern. Also, mechanistic trials are not supported unless the primary focus of the project is on technology development.
Section II. Award Information
Funds Available and Anticipated Number of Awards
Currently Reads:
The following NIH components intend to commit the following amounts for the duration of this PAR:
NINDS intends to commit up to $10 million per fiscal year, approximately 25 awards, dependent on award amounts
NIDA intends to commit up to $5 million per fiscal year, 12-15 awards, dependent on award amounts
NIMH intends to commit up to $5 million per fiscal year, 12-15 awards, dependent on award amounts
NINR intends to commit up to $1 million per fiscal year, 2-3 awards, dependent on award amounts
NIAAA intends to commit up to $1.5 million per fiscal year, 2-3 awards, dependent on award amounts
NCCIH intends to commit up to $400,000 per fiscal year, 1 award, dependent on award amounts
Future year amounts will depend on annual appropriations.
Modified to Read (changes shown in bold italics):
The following NIH components intend to commit the following amounts for the duration of this PAR:
NINDS intends to commit up to $10 million per fiscal year, approximately 25 awards, dependent on award amounts
NIDA intends to commit up to $5 million per fiscal year, 12-15 awards, dependent on award amounts
NIMH intends to commit up to $5 million per fiscal year, 12-15 awards, dependent on award amounts
NINR intends to commit up to $1 million per fiscal year, 2-3 awards, dependent on award amounts
NIAAA intends to commit up to $1.5 million per fiscal year, 2-3 awards, dependent on award amounts
NCCIH intends to commit up to $400,000 per fiscal year, 1 award, dependent on award amounts
NIBIB's number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Future year amounts will depend on annual appropriations.
Section VII. Agency Contacts
Scientific/Research Contact(s)
Currently Reads:
Will M. Aklin, Ph.D.
National Institute on Drug Abuse (NIDA)
Telephone: 301-827-5909
Email: [email protected]
Michelle Jones-London, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-451-7966
Email: [email protected]
Lauren D. Hill, PhD
National Institute of Mental Health (NIMH)
Telephone: 301-443-2638
Email: [email protected]
Shalanda A. Bynum, PhD, MPH
National Institute of Nursing Research (NINR)
Telephone: 301-755-4355
Email: [email protected]
Laura Kwako, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-451-8507
Email: [email protected]
Beda Jean-Francois
National Center for Complementary & Integrative Health (NCCIH)
Telephone: 202-313-2144
Email: [email protected]
Neeraj Agarwal, PhD
National Eye Institute (NEI)
Telephone: 301-435-8155
Email:[email protected]
Modified to Read (changes shown in bold italics):
Will M. Aklin, Ph.D.
National Institute on Drug Abuse (NIDA)
Telephone: 301-827-5909
Email: [email protected]
Michelle Jones-London, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-451-7966
Email: [email protected]
Lauren D. Hill, PhD
National Institute of Mental Health (NIMH)
Telephone: 301-443-2638
Email: [email protected]
Shalanda A. Bynum, PhD, MPH
National Institute of Nursing Research (NINR)
Telephone: 301-755-4355
Email: [email protected]
Laura Kwako, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-451-8507
Email: [email protected]
Beda Jean-Francois
National Center for Complementary & Integrative Health (NCCIH)
Telephone: 202-313-2144
Email: [email protected]
Neeraj Agarwal, PhD
National Eye Institute (NEI)
Telephone: 301-435-8155
Email:[email protected]
Albert Avila, Ph.D.
National Institute on Biomedical Imaging and Bioengineering (NIBIB)
Telephone: 301-496-8804
Email: [email protected]
Financial/Grants Management Contact(s)
Currently Reads:
Pamela Fleming
National Institute on Drug Abuse (NIDA)
Telephone: 301-253-8927
Email: [email protected]
Chief Grants Management Officer
National Institute of Neurological Disorders and Stroke (NINDS)
Email: [email protected]
Terri Jarosik
National Institute of Mental Health (NIMH)
Telephone: 301-443-3858
Email: [email protected]
Kelli Oster
National Institute of Nursing Research (NINR)
Telephone: 301-594-2177
Email: [email protected]
Judy Fox
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-4707
Email: [email protected]
Debbie Chen
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-3788
Email: [email protected]
Karen Robinson-Smith
National Eye Institute (NEI)
Telephone: 301-435-8178
Email: [email protected]
Modified to Read (changes shown in bold italics):
Pamela Fleming
National Institute on Drug Abuse (NIDA)
Telephone: 301-253-8927
Email: [email protected]
Chief Grants Management Officer
National Institute of Neurological Disorders and Stroke (NINDS)
Email: [email protected]
Terri Jarosik
National Institute of Mental Health (NIMH)
Telephone: 301-443-3858
Email: [email protected]
Kelli Oster
National Institute of Nursing Research (NINR)
Telephone: 301-594-2177
Email: [email protected]
Judy Fox
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-4707
Email: [email protected]
Debbie Chen
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-3788
Email: [email protected]
Karen Robinson-Smith
National Eye Institute (NEI)
Telephone: 301-435-8178
Email: [email protected]
Albert Avila, Ph.D.
National Institute on Biomedical Imaging and Bioengineering (NIBIB)
Telephone: 301-496-8804
Email: [email protected]
Albert Avila
National Institute of Biomedical Imaging and Bioengineering
Telephone: 301-496-8804
Email:[email protected]