Notice of Intent to Publish a Funding Opportunity Announcement for NIBIB Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
October 03, 2022
Estimated Publication Date of Funding Opportunity Announcement:
November 15, 2022
First Estimated Application Due Date:
February 16, 2023
Earliest Estimated Award Date:
November 30, 2023
Earliest Estimated Start Date:
December 30, 2023
Related Announcements


Issued by

National Institute of Biomedical Imaging and Bioengineering (NIBIB)


The National Institute of Biomedical Imaging and Bioengineering, with other NIH Institutes and Centers (ICs) The National Institute on Aging, The National Eye Institute , intends to promote an initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for research to pursue research programs of high interest to the NIH that integrate engineering and the physical sciences with the life and/or biomedical sciences.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published about 11/15/2022 with an expected application due date about 2/16/2023.

This FOA will utilize the R21 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Trailblazer Award is an opportunity for NIH-defined New and Early Stage Investigators ( to pursue research programs that integrate engineering and the physical sciences with the life and/or biomedical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high risk-high impact, and may be technology design-directed, discovery-driven, or hypothesis-driven. Importantly, applicants must propose research approaches for which there are minimal or no preliminary data.

A distinct feature for this FOA is that no preliminary data are required, expected, or encouraged. However, if available, minimal preliminary data are allowed. Preliminary data are defined as material which the applicant has independently produced and not yet published in a peer-reviewed journal. All preliminary data should be clearly marked and limited to one-half page, which may include one figure. Applications including data more than one-half page or more than one figure will be considered noncompliant with the FOA instructions and will not go forward to review.

Funding Information


Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Randy King, Ph.D.
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Telephone: 301-451-0707