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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research on Type 1 Diabetic (T1D) nephropathy. This NOFO requests applications for Recruitment Sites (RS) to enroll adult and/or pediatric patients with T1D with, or at high risk of, diabetic nephropathy into a longitudinal cohort study and perform protocol-based research kidney biopsies. These T1D RS will leverage and expand the existing resources of the Kidney Precision Medicine Project (KPMP). T1D RS will collaborate directly with the KPMP to obtain and evaluate kidney biopsies from participants, create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies, focused on T1D nephropathy. Information regarding KPMP, including study protocols can be found at About (kpmp.org). Processing of kidney biopsies tissues obtained from the RS, as well as atlas development, will be managed by the KPMP Consortium. Interested potential applicants are encouraged to contact the NIDDK individuals listed below.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The NOFO is expected to be published in the fall of 2024 with an expected application due date in late fall 2024.
This NOFO will utilize the U01 cooperative agreement award activity code. Details of the planned NOFO are provided below.
This Notice encourages investigators with expertise and insights into this area of T1D nephropathy to begin to consider applying for this new NOFO.
In addition, collaborative investigations combining expertise in patient recruitment and engagement and endocrinology will be encouraged, and these investigators should also begin considering applying for this application.
Among the areas of research encouraged in this initiative are nephrology and endocrinology research examining the mechanisms that underlie the effects of T1D nephropathy, as well as research designed to improve the translation of existing knowledge of strategies for the prevention and treatment of T1D nephropathy.
$1.3 million total costs
TBD
93.847
Applications are not being solicited at this time.
Please direct all inquiries to:
Afshin Parsa M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-827-1375
Email: Afshin.parsa@nih.gov