Notice of Intent to Publish a Funding Opportunity Announcement for A Consortium for Gut-Brain Communication in Parkinson’s Disease (U01 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:
January 25, 2023
Estimated Publication Date of Funding Opportunity Announcement:
May 01, 2023
First Estimated Application Due Date:
October 10, 2023
Earliest Estimated Award Date:
July 02, 2024
Earliest Estimated Start Date:
July 02, 2024
Related Announcements

NOT-DK-23-007 - Notice of Intent to Publish a Funding Opportunity Announcement for A Consortium for Gut-Brain Communication in Parkinson's Disease (U24 Clinical Trial Not Allowed)

Issued by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


This notice is to inform the research community that National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications to participate in the Gut-Brain Communication in Parkinson’s Disease (PD) Consortium (GBPDC). The goals of this initiative are:

1) to establish a network of individual research projects and a Coordinating and Data Management Center (CDMC) focused on clinical research; 2) recruitment of sufficient patients and use of standardized protocols to collect data and biospecimens relevant to both neurology and gastroenterology research; 3) share data, biomaterials, models, reagents, resources and methods among projects in the GBPDC; and 4) make these publicly available through the CDMC.

The objective of this consortium is to accelerate research on the role of gastrointestinal (GI) symptoms and changes in gut-brain communication in the initiation and pathogenesis of Parkinson’s disease in order to facilitate development and validation of innovative early-phase GI-based diagnostic tools and biomarkers for PD. The research centers of the GBPDC will serve as sites for enrollment of PD patients and healthy age-matched controls for longitudinal studies involving the clinical assessment of relevant neurologic and GI function as well as laboratory-based studies on biological samples obtained from these patients.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in Spring, 2023 with an expected application due date in Fall, 2023.

This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages clinical investigators and interests in the area of gut brain communication in Parkinson's disease (PD) to consider applying for this new FOA.

Applications should show documented expertise in the clinical areas of Gastroenterology and Neurology to bring multidisciplinary and innovative approaches to understanding of the temporal onset of GI symptoms and changes in gut to brain communication in PD to leverage the potential role of the GI tract in the pathogenesis and progress of PD to improve patient diagnosis, care, and outcomes.

Awardees will form a consortium, governed by a steering committee of investigators and NIH staff that will develop consensus policies and procedures for Consortium-wide activities including data and resource sharing.

Funding Information


Estimated Total Funding


Expected Number of Awards

5-6 awards, contingent upon availability of funds and receipt of meritorious applications

Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time.


Terez Shea-Donohue, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301 825-2314