Notice of Intent to Publish a Funding Opportunity Announcement for Advancing Research on Mechanisms and Management of Pain for Diseases and Conditions within NIDDK Mission Areas (R01 Clinical Trial Optional)
Notice Number:
NOT-DK-22-007

Key Dates

Release Date:
December 10, 2021
Estimated Publication Date of Funding Opportunity Announcement:
February 15, 2022
First Estimated Application Due Date:
May 17, 2022
Earliest Estimated Award Date:
September 15, 2022
Earliest Estimated Start Date:
December 01, 2022
Related Announcements

None

Issued by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Purpose

The purpose of this Notice is to inform the community that the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) intends to publish a Funding Opportunity Announcement (FOA) that will invite broad investigator-initiated research projects proposing novel basic, translational, and clinical studies and efforts to develop new approaches to assess and treat pain for disorders within the NIDDK mission areas.

This upcoming FOA is expected to be published in the Winter of 2022 with an expected application due date in the Spring 2022. It will utilize the Research Project Grant (R01 Clinical Trial Optional) mechanism.

This Notice is provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This will be an open competition.

Research Initiative Details

Pain is a common and often debilitating symptom of numerous diseases and conditions and results in broad morbidity and a greatly diminished quality of life. While pain affects men and women of all ages, women are at greater risk of developing chronic pain conditions than men and pain is especially prevalent in the elderly. In addition, pain can be particularly impactful to underserved populations due to inadequate healthcare.

The impact of pain on patient quality of life for diseases and conditions within the mission of the NIDDK is enormous. However, for these conditions there is an insufficient understanding of the underlying biological and clinical contributors of pain. In addition, new clinical management strategies that better measure, predict, and target pain and improve upon current interventions, such as opioids therapy, are critically needed for affected patients, including for both adult and pediatric populations, as appropriate. To accelerate critical advances in defining and treating pain in NIDDK mission areas additional, broad research efforts are critically needed.

To address these needs the planned FOA will invite investigator-initiated applications designed to address critical questions of pain as a component of diabetic neuropathy; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases. This Notice encourages investigators with expertise and insights into these areas to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise will be encouraged and these investigators should also begin considering applying for this application.

Information gained is expected to significantly advance the characterization of pain as a defining symptom for relevant diseases and disorders within NIDDK mission interests, as well as inform new clinical strategies for improving pain management and outcomes in affected patient populations. Studies proposing multi-disciplinary approaches and diverse expertise, that follow upon recent advances, and leverage unique methodologies or resources will be encouraged.

Funding Information
Estimated Total Funding

TBD

Expected Number of Awards
TBD
Estimated Award Ceiling

TBD

Primary Assistance Listing Number(s)

93.847

Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 

Inquiries

Please direct all inquiries to:

Chris Mullins, PhD
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)  
301-451-4902
mullinsc@mail.nih.gov

Dana K. Andersen, MD
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 410-868-0638
Email: dana.andersen@nih.gov

Teresa Jones, MD
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: 301-435-2996
Email: teresa.jones@nih.gov