PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIDDK is issuing this Notice of Special Interest (NOSI) to announce the opportunity for investigators with active NIDDK-supported R01 grants that focus on Polycystic Kidney Disease (PKD) to apply for administrative supplements. The intent of these supplements is to catalyze and accelerate the pace and achievement of scientific research related to PKD. The proposed projects must be within the scope of the currently active R01 award.
Background
Understanding and ameliorating autosomal dominant PKD and autosomal recessive PKD are central to the mission of NIDDK. The clinical course of these diseases is highly variable; some patients develop only a modest number of renal cysts, while others develop a massive number of renal cysts and renal failure at an early age. The diseases have extra-renal manifestations, including in liver and systemic vasculature, with variable penetrance. Despite important advances in elucidating causative genetic defects, many challenges remain in determining other genetic and pathophysiologic mechanisms of PKD that could potentially be targeted for therapeutic interventions. Recognizing the need for interdisciplinary, integrated approaches for identification of novel therapies, this NOSI is issued to catalyze cutting edge research into the causes, pathophysiology and treatment of PKD.
Research Objectives
To catalyze and accelerate the pace and achievement of scientific research related to PKD, the NIDDK is encouraging the submission of applications for Administrative Supplements to active, NIDDK-supported R01 grants focused on PKD. The NIDDK intends to accept applications for supplements under this notice in all scientific areas within the scope of the funded R01 and examples of research areas of interest include, but are not limited to:
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
All instructions in the SF424 (R&R) Application Guide and PA-18-591 must be followed, with the following additions:
Susan Mendley, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-827-1861
Email: susan.mendley@nih.gov
Christine Maric-Bilkan, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-435-0486
Email: christine.maric-bilkan@nih.gov