Notice Number: NOT-DK-20-004
Key Dates
Release Date: January 16, 2020
Response Date: February 28, 2020
Issued by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Heart, Lung, and Blood Institute (NHLBI)
Office of Behavioral and Social Sciences Research (OBSSR)
Office of Disease Prevention (ODP)
Purpose
The purpose of this Request for Information (RFI) is to solicit innovative ideas to better characterize risk factors and understand the underlying mechanisms through which these factors contribute to the development of obesity during early childhood. The goal is to develop innovative, targeted and more effective strategies for childhood obesity prevention.
Background
Obesity in children and adolescents has increased dramatically over the past three decades and continues to be a major public health problem (1). Obesity prevention and treatment approaches for children are limited and most behavioral interventions show, on average, only modestly favorable changes in Body Mass Index (BMI) which are not sustained (2,3). Substantial inter-individual differences also exist in response to interventions, and we cannot predict consistently who will or will not respond to a given intervention strategy.
The trajectory of BMI during childhood is predictive of obesity in later years. A meta-analysis of 15 prospective cohort studies found that about 55% of children with obesity continue to have obesity during adolescence and 80% of adolescents with obesity continue to have obesity in young adulthood (4). For children and adolescents with obesity, compared to those of normal weight, there is a 5 times greater risk of having obesity in young adulthood.
Studies also have shown that accelerated growth patterns during infancy and childhood are associated with a higher risk of overweight or obesity in adolescence and/or adulthood. A meta-analysis of 14 cohort studies found that rapid weight gain during the first 2 years of life was associated with approximately a 4-fold greater risk for developing overweight or obesity from childhood to adulthood (5). Research also suggests that high-risk growth trajectories or patterns emerge during infancy and early childhood, and tend to persist, suggesting critical periods in the development of overweight and obesity (5,6,7).
Significant progress has been made in identifying behavioral, biological, psychosocial, and environmental factors that place children at a higher or lower risk of developing obesity. Yet, the complex mechanisms that underlie how these factors contribute to excess weight gain or adiposity are not well understood. Characterizing highly predictive metabolic and biobehavioral phenotypes that emerge during infancy and early childhood and uncovering mechanisms that underlieindividual susceptibility to developing childhood obesity will help to develop more targeted and effective prevention strategies beginning at an early age.
Information Requested
This RFI seeks input from stakeholders throughout the scientific research community and the public regarding any of the following topics, as well as any additional ideas not included below:
How to Submit a Response
All responses to this RFI must be submitted electronically to the following email at [email protected] by 11:59 PM, EST, on February 28, 2020.
Responses to this RFI are voluntary. Do not include any proprietary, classified, confidential, or sensitive information in your response. The NIH will use the information submitted in response to this RFI at its discretion and will not provide comments to any respondent's submission. The collected information will be reviewed by federal staff, may appear in reports, and may be shared publicly on any federal website.
The Government reserves the right to use any non-proprietary technical information in summaries of the state of the science, and any resultant solicitation(s). The NIH may use the information gathered by this RFI to inform the development of future funding opportunity announcements.
This RFI is for information and planning purposes only and should not be construed as a solicitation or as an obligation on the part of the Federal Government, the National Institutes of Health (NIH), or individual NIH Institutes and Centers. No basis for claims against the U.S. Government shall arise as a result of a response to this request for information or from the Government’s use of such information.
Citations
Inquiries
Please direct all inquiries to:
Voula Osganian, MD, ScD, MPH
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phone: (301) 827-6939
Email: [email protected]