Notice of Special Interest: Nutrigenetics and Nutrigenomics Approaches for Nutrition Research

Notice Number: NOT-DK-19-019

Key Dates
Release Date: September 25, 2019
First Available Due Date: February 5, 2020
Expiration Date: January 8, 2022

Related Announcements

PA-19-055Research Project Grant (Parent R01 Clinical Trial Required)

PA-19-056NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-18-330Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required)

Issued by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Center for Complementary and Integrative Health (NCCIH)

Purpose

The purpose of this Notice of Special Interest is to foster collaborative research between nutrition researchers and experts in omics technologies and encourages applications that employ nutrigenetics and/or nutrigenomics approaches to basic, translational and clinical nutrition research. Collaboration between investigators with demonstrated expertise in nutrition research and omics techniques is highly encouraged.

Examples of the application of nutrigenetics and nutrigenomics approaches to nutrition research include but are not limited to:

  • Impact of genetic polymorphisms on nutrient absorption, transport and metabolism
  • Impact of nutrients and dietary components on gene expression that affect nutrient absorption, transport and metabolism in target tissues and relevant bio-specimens in health and diseases relevance to participating NIH Institutes
  • Mechanisms by which specific nutrients/dietary components modulate intestinal physiology (transporters), barrier function, inflammation, and/or microbiome composition
  • Mechanisms by which nutrient sensing in the gut is transduced to extra- intestinal organs and tissues
  • Studies that explore the interaction/competition between various nutrients for their absorption, transport, metabolism and elimination
  • Studies that explore the interaction/competition between various nutrients and drugs for their absorption, transport, metabolism and elimination
  • Impact of nutrient excess and deficiency in health and diseases relevant to participating NIH Institutes
  • Mechanism of action of prebiotics and resistant starches on intestinal function and host metabolism, and
  • Mechanism of action of probiotics and secreted probiotic factors on intestinal function and host metabolism

Potential applicants to National Center for Comprehensive and Integrative Health (NCCIH) are encouraged to read the following information on IC-specific research interests.

The National Center for Complementary and Integrative Health (NCCIH) is particularly interested in nutrigenetic and nutigenomic-based mechanistic studies of interaction and competition between nutrient-nutrient, nutrient-drug, dietary supplements, and probiotics/prebiotics on host-microbial metabolism, immunologic/inflammatory signaling, neuro-hormonal pathways and target tissues [including bio-availability, absorption, transport, metabolism and excretion studies] that impact the basic fundamentals that will eventually lead to a better understanding of the gut brain function in health promotion and disease prevention. NCCIH is also interested in the impact of [selected] nutrient, dietary supplements, the ketogenic diet, and probiotic/prebiotic modulation of specific conditions including pain. In addition, NCCIH is interested in supporting applications studying mechanisms of how botanical products, prebiotics, Omega-3 fatty acids and other dietary supplements, in delineating their relationship to pain and inflammation. NCCIH will not support trials for the prevention and treatment of cancer.

Application and Submission Information

This Notice applies to due dates on or after February 5, 2020 and expires on January 8, 2022.

The following funding opportunity announcements (FOAs) or their reissued equivalents must be used for submissions for this initiative. Although NIDDK and NCCIH are not listed as Participating Organizations in all the FOAs listed below, applications for this initiative will be accepted.

Applications in response to this Notice that do not involve clinical trials must be submitted through PA-19-056, NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed). All instructions for PA-19-056 must be followed. Applications proposing clinical trials must be submitted through PA-18-330, Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required) or PA-19-055 (Research Project Grant, Clinical Trial Parent R01) and follow NOT-AT-19-011, NCCIH Only Accepts Clinical Trial Applications Proposing Mechanistic Studies for Clinical Trial Parent R01 Announcements.

Investigators planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research/aims with the IC program officers listed on this NOSI, well in advance of the application due date.

Activity Code FOA Number and Title First Available Due Date
R01 PA-19-055: Research Project Grant (Parent R01 Clinical Trial Required) February 5, 2020
R01 PA-19-056: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) February 5, 2020
R01 PA-18-330: Investigator-Initiated Clinical Trials Targeting Diseases within the Mission of NIDDK (R01 Clinical Trial Required) February 5, 2020



For funding consideration, applicants must include NOT-DK-19-019 in the Agency Routing Identifier field (Box 4.b) of the SF 424 (R&R) Form. Applications without this information in Box 4.b will not be considered for this initiative.

Applications nonresponsive to the terms of this Notice will not be considered for this initiative.

Inquiries

Please direct all inquiries to:

Padma Maruvada
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: ( 301) 594-8884
Email: padma.maruvada@nih.gov

Yisong Wang
National Center for Complementary and Integrative Health (NCCIH)
Telephone: (301) 480-9483
Email: yisong.wang@nih.gov