Request for Information (RFI). Needs for Preclinical Efficacy Testing of Promising Agents to Prevent or Reverse Diabetic Complications

Notice Number: NOT-DK-09-009

Key Dates
Release Date:  March 17, 2009

Issued by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), (

Purpose:  The purpose of this request for information (RFI) is to gather information from the scientific community about current needs and emerging opportunities in therapeutics development for diabetic complications.  The National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) seeks to identify new therapeutic or intervention strategies currently under development that may be facilitated by expanded in vivo preclinical testing. 

Background: As part of its mission to facilitate therapeutics development along the translational continuum, the NIDDK has established a contract to support expanded preclinical testing for therapies to prevent or reverse the complications of type 1 diabetes (  The contract supports the resources and expertise needed to acquire expanded preclinical therapeutic efficacy data in rodent models of diabetic complications.  

Information is needed to gauge specific needs of the investigator community for these services. 

Information Requested: We seek to identify scientists with promising new therapeutics or intervention strategies in early stages of development that may require further efficacy testing in rodent models.  Investigators working in diabetic complications with preclinical testing needs should respond to this RFI by providing a brief description of the intervention concept and relevant preliminary data supporting therapeutic promise.

Reponses: Please refer to this notice in any communications, and respond by email to:

This RFI is for information purposes only and should not be construed as a solicitation or as an obligation on the part of the NIDDK. The NIDDK does not intend to award a grant or contract to pay for the preparation of any information submitted or for the NIDDK’s use of such information.  Responses will be held confidential.  Any proprietary information should be so marked.


Inquiries regarding this notice may be directed to:

Kristin M. Abraham, Ph.D.
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd. Rm. 795
Bethesda, MD 20892-5460
Telephone: (301) 451-8048
FAX: (301) 480-0475

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