NOT-DK-01-017: PRECLINICAL TOXICITY OF IRON CHELATORS: RFP AVAILABLE

Department of Health
and Human Services (HHS)

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PRECLINICAL TOXICITY OF IRON CHELATORS:  RFP AVAILABLE

Release Date:  November 27, 2001

NOTICE:  NOT-DK-01-017

National Institute of Diabetes and Digestive and Kidney Diseases

The National Institute of Diabetes and Digestive and Kidney Diseases 
(NIDDK) of the National Institutes of Health (NIH) is seeking an 
organization or an institution to perform preclinical toxicity studies 
of iron chelating compounds for potential use in the safe and effective 
removal of iron deposits in patients with iron overload conditions 
(e.g., Cooley"s anemia).  A clinical evaluation is not desired at this 
time.  The contractor shall conduct toxicologic and related studies of 
selected iron chelating compounds, in rats, dogs and other model 
systems as directed by the Project Officer, and shall assist the NIDDK 
and its scientific consultants by preparing reports based on the 
resulting toxicologic information for submission as Investigational New 
Drug applications (IND) to the Food and Drug Administration (FDA) for 
approval of eventual clinical studies.  The drugs under development are 
considered to be orphan drugs.  The Requests for Proposals, RFP No. 
NIH-NIDDK-01-10 will be issued on or about November 9, 2001 with a 
closing date on or about February 8, 2002.  Requests for the RFP must 
be in writing (by mail, fax, or e-mail) addressed to the Contracting 
Officer cited below, and must cite the referenced RFP number.  
Telephone requests will not be honored. All responsible sources may 
submit a proposal that will be considered by the agency.  The 
Government is not committed to award a contract pursuant to this 
announcement.

Robert T. Coonley, Contracting Officer
R&D Contracts Section, Acquisition Management Branch
National Institute of Diabetes, and Digestive and Kidney Diseases, NIH
2 Democracy Plaza, Room 780
6707 DEMOCRACY BLVD MSC 5455
BETHESDA, MD  20892-5455
Telephone:  (301) 594-8837
Fax:  (301) 480-8261
E-Mail:  [email protected]

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