Release Date:  December 13, 1999

NOTICE:  DK-00-001

National Institute of Diabetes and Digestive and Kidney Diseases

The National Institute of Diabetes and Digestive and Kidney Diseases 
(NIDDK) announces the availability of administrative supplements to NIDDK 
grantees to facilitate the development and application of microarray or 
other gene profiling technologies. The NIDDK ultimately wishes to 
facilitate wide dissemination of these methods and associated resources 
to NIDDK grantees. An RFA for gene expression resources to support 
projects in areas within the NIDDK’s mission (DK-00-002) has been issued 
(NIH Guide, September 23, 1999) and is available at This 
administrative supplement program is designed to provide a temporary 
mechanism to enable NIDDK investigators to use comprehensive gene 
profiling methods.

Investigators currently supported by the following grant mechanisms 
funded by NIDDK are eligible to apply: research project (R01), MERIT 
award (R37), program project (P01), special centers of excellence 
(P50), and research project cooperative agreement (U01). The work 
proposed must be within the scope of the research originally 
recommended by peer-review. Applicants can request one year of support 
for no more than $35,000 in direct costs. Projects must have one year 
or more remaining at the time of the anticipated supplement (September 
30, 1999). 

Each investigator may only submit one application. There is no 
restriction on the type of gene profiling technology that the 
applicant may select. Examples of research areas appropriate to this 
announcement include, but are not limited to (1) determination of 
global gene expression patterns and monitoring of changes under 
normal and experimental/pathological conditions; (2) identification 
of novel expressed sequence tags (ESTs) involved in normal function 
and pathogenesis of disease; (3) development of efficient 
experimental protocols for using cDNA arrays to study gene expression 
patterns in human or animal tissues, including methods to prepare 
hybridization probes from small pathology specimens, micro-dissected 
tissues, or single cells; (4) enhancement of currently available gene 
profiling analysis tools, including data tracking, image analysis, 
and bioinformatics tools; (5) development of higher-order analysis 
tools and software algorithms to process gene expression data to 
predict gene-gene interactions and functional pathways.

NIDDK has set aside up to $1 million in FY 2000 for this one-time 
announcement.  Requests must be received by March 15, 2000. To apply 
for a supplement, send an original letter and 2 copies countersigned 
by the grantee institution’s business officer to Dr. Robert A. Star 
at the address below. 

The letter (5 page limit) must include: 1) an abstract of the 
proposed supplemental activity; 2) a detailed description of the 
proposed activity, including methodology and resources available; 3) 
impact of the requested supplement on ongoing research; 4) expected 
outcome; 5) a budget of no more than $35,000 in direct costs for the 
one year, carefully justifying methodologies, technologies, 
bioinformatics, statistical analytical tools, data-sharing 
arrangements, and costs; 6) any pre-existing intellectual property 
rights, including options to for-profit research sponsors, associated 
with the clones, sequences, and experimental results that may be 
generated; and 7) current PI e-mail address. Although these 
descriptions should be as concise as possible, sufficient detail must 
be provided to allow the NIDDK to judge the merit of the requested 
supplement. The current aims of the parent grant should be submitted 
as a separate attachment (not included in the 5-page limit).

NIDDK will consider supplement requests from all eligible applicants. 
However, because funds are limited, highest priority will be given to 
supplement requests that meet the following criteria:

o The proposed experiments are within the scope of the funded project 
and will significantly improve its progress.

o The applicant has the resources and expertise necessary to perform 
the experiments and agrees to release data in a timely manner.

o The applicant’s plans for quality control and bioinformatics 
support are adequate.

o The applicant has carefully documented and justified the requested 

Grantees are encouraged to discuss the request with their NIDDK 
program director or the individuals listed below before applying.  In 
addition, please send an e-mail to 
indicating the correct e-mail and mailing address of the applicant.  
PROFILING METHODS” in the subject field. Acknowledgement of receipt 
of the supplement letter will be provided by email.  The request will 
be evaluated and prioritized by an NIDDK committee of extramural 
scientific staff with expertise in the scientific area. No written 
critique will be provided. Award decisions will be based upon 
000000scientific merit, availability of funds, and programmatic 
priorities, including program relevance of the hypothesis-driven 
scientific project that will be aided by the advanced technology.  
Funds will be awarded by September 30, 2000.

Answers to Frequently Asked Questions (FAQ) will be available at under FAQ.  Direct inquiries regarding 
programmatic issues to:

Robert A. Star, M.D.
Division of Kidney, Urologic, and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
45 Center Drive MSC 6600
Bethesda, MD 20892-6600
Phone: (301) 594-7715
FAX: (301) 480-3510

Philip F. Smith, Ph.D.
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
45 Center Drive MSC 6600
Bethesda MD 20892-6600
Phone: (301) 594-8816
FAX: (301) 480-3503

Jose Serrano, M.D., Ph.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
45 Center Drive MSC 6600
Bethesda MD 20892-6600
Phone: (301) 594-8871
FAX: (301) 480-8300

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