Notice of Special Interest (NOSI): Administrative Supplements for NIDCR Grants to Support Pain-Focused High Priority Research Areas
Notice Number:

Key Dates

Release Date:

January 11, 2022

First Available Due Date:
February 10, 2022
Expiration Date:
May 03, 2022

Related Announcements

PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Issued by

National Institute of Dental and Craniofacial Research (NIDCR)


The National Institute of Dental and Craniofacial Research (NIDCR) is inviting NIDCR-supported projects to expand existing awards to enhance high priority pain research through collecting additional data to strengthen scientific and technical approaches to the study design, and/or developing preliminary data for future lines of inquiry in pain research. Active awards with project end dates in FY2023 or later are eligible. Grants in no-cost extension or going into no-cost extension in FY2022 are not eligible for administrative supplement awards.

The research areas of interest for the supplemental project must be directly related to mechanism, diagnosis, prevention, management/treatment, and/or outcomes of orofacial pain including cancer related pain. Examples include but are not limited to:

  • Leveraging existing dataset or repository for secondary analysis and data reuse for pain research
  • Validating biomarkers or biomarker signatures for painful temporomandibular disorders (TMDs)
  • Identifying novel non-opioid therapeutic targets of pain
  • Assessing neuroimmune interactions in painful TMDs, for example peripheral and/or central interactions leading to chronic pain.
  • Exploring the willingness/acceptability of screening for orofacial pain conditions or opioid use disorders (OUDs) in dental settings.
  • Enhancing pain assessment by combining subjective and objective pain assessments and/or using technology that captures self-reported (subjective) pain measurements
  • Identifying biological, environmental, or social determinants of disparities in pain perception or management

NIDCR also encourages the proposed supplemental work to involve new collaborators, including early career investigators, or those who can offer new and diverse perspectives to orofacial pain research.

Research training, institutional Career Development, and research education awards with the following activity codes are not eligible to apply: F30, F31, F32, F99, T32, T90, R90, D43, K12, and R25. NIDCR-supported, active individual mentored Career Development awards (K01, K08, K22, K23, K25, K43, K99) are eligible for this supplemental support if the supplemental project is within the scope of the parent award as specified above. Awardees are encouraged to seek competing support to continue promising leads from the research supported through this supplement opportunity.

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:

  • Application Due Date(s) – Applications may be submitted any time and will be reviewed and considered on a rolling basis. To be considered for funding in FY22, applications must be submitted no later than May 2, 2022, by 5:00 PM local time of applicant organization.
  • For funding consideration, applicants must include “NOT-DE-22-002” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Requests are limited to one year of support only.
  • Administrative supplement requests are limited to no more than the total direct cost of the parent award.
  • Applicants may apply for only one supplement to a given parent grant/award under this NOSI.
  • The Research Strategy section of the application is limited to 6 pages.
  • As part of the Research Strategy, investigators must provide a detailed description of the proposed research that includes a timeline demonstrating feasibility of supplemental project completion within the proposed time and budget. The Research Strategy must also describe how the supplemental project enhances the significance and impact of the parent project. The work may include pilot projects or resource development within the scope of the parent award.

Review Process

NIDCR will conduct administrative reviews of all applications.


  • Is the work proposed within the scope of the active award?
  • Does the proposed research focus on mechanism, diagnosis, prevention, management/treatment, and/or outcomes of orofacial pain?
  • Is the supplement research project likely to stimulate continued research activity leading to progress in the specified topic of pain research?
  • Has sufficient progress been made in the parent grant to justify for supplemental work?


Please direct all inquiries to the program officer listed in each NIDCR award.