Revision: Notice of Intent to Publish a Funding Opportunity Announcement for National Dental Practice-Based Research Network: Administrative and Resource Center (U19 Clinical Trial Required)

Notice Number: NOT-DE-18-009

Key Dates

Release Date:February 08, 2018
Estimated Publication Date of Funding Opportunity Announcement: 02/28/2018 
First Estimated Application Due Date: 07/16/2018 
Earliest Estimated Award Date: 03/01/2019 
Earliest Estimated Start Date: 04/01/2019 

Related Announcements

Rescinded: NOT-DE-18-003
Rescinded: NOT-DE-18-004

Issued by
National Institute of Dental and Craniofacial Research (NIDCR)


NOT-DE-18-003 incorrectly listed the estimated publication date of the Funding Opportunity Announcement (FOA) and the first estimated application due date and is being rescinded. The NIDCR intends to continue support for research conducted within a national Dental Practice-Based Research Network (DPBRN) by publishing two companion FOAs. One FOA will solicit applications for the national DPBRN Administrative and Resource Center (U19) led by a National Network Director or Directors, and a separate companion FOA will solicit applications for the national DPBRN Coordinating Center (U01). The potential awards will support the infrastructure for and implementation of multiple observational studies and clinical trials.
The FOA is expected to be published in February 28, 2018 with an expected application due date in mid-July 2018.

This FOA will utilize the U19 activity code. This Notice is provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators who have expertise in and insights about conducting research within a DPBRN to begin to consider applying for this planned U19 FOA.

Practice-based research networks can generate important and timely information to guide the delivery of health care and improve patient outcomes. A DPBRN is a unique venue in which to conduct clinical research. It provides dental practitioners with an opportunity to propose or participate in research studies, conducted in participating dental offices with consenting patients. DPBRN studies draw on the experience and insight of practicing clinicians to help identify and frame research questions, which typically address issues faced by dental practitioners in the daily care of their patients. Because research is conducted in the real-world environment of dental practice, results have the potential to be readily accepted and adopted by practitioners and translated into daily practice. DPBRNs can support a variety of clinical studies to help expand and strengthen the profession’s evidence base and further refine care.
The main goals of this FOA are to efficiently conduct national oral health research studies in dental practices on topics of importance to practitioners and their patients, to provide evidence useful in daily patient care, and to facilitate the translation of research findings into clinical practice. It is expected that the DPBRN will continue work of the previous DPBRNs funded by NIDCR and will incorporate refinements based on published findings from the earlier phases.
The FOA described in this Notice will solicit applications for the national DPBRN Administrative and Resource Center, which will coordinate efforts of dental practitioners and their practices and clinics through a network structure and will maintain a geographically diverse network capable of reaching all interested participants. The DPBRN will develop and conduct multiple national oral health clinical studies, including clinical trials, during the project period.
The planned U19 FOA will include funds to support developmental/exploratory, pilot, and/or survey studies to be conducted in the DPBRN; a future FOA will solicit applications for investigator-initiated clinical observational studies and clinical trials to be conducted in the DPBRN.
Intent to publish a separate FOA for the national DPBRN Coordinating Center (U01) is described in a separate Notice for National Dental Practice-Based Research Network: Coordinating Center (NOT-DE-18-006). The PI for an application in response to this FOA may not be the PI for the companion application in response to the national DPBRN Coordinating Center FOA.

Funding Information

Estimated Total Funding TBD
Expected Number of Awards TBD
Estimated Award Ceiling TBD
Primary CFDA Numbers 93.121

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization

Applications are not being solicited at this time.


Please direct all inquiries to:

Center for Clinical Research
Division of Extramural Research
National Institute of Dental and Craniofacial Research (NIDCR)
All inquiries should be sent to: