Notice Number: NOT-DE-06-003

Key Dates
Release Date: August 31, 2006

Issued by
National Institute of Dental and Craniofacial Research (NIDCR), (http://www.nidcr.nih.gov/)

Additional information on FOAs PA-06-188, PA-06-267, and PA-06-268, Temporomandibular Joint and Muscle Disorders: Pathophysiological Mechanisms Linking Comorbid Conditions (R01) (R03) (R21)

The prevalence of temporomandibular joint and muscle disorders and many other chronic painful conditions is higher in women than men. Women tend to seek medical attention for these disorders at a much higher rate than men. Studies suggest that estrogen may predispose women to a higher sensitivity to noxious stimuli. Clearly sex and gender influences will modify the sensitivity of individuals to painful stimuli and responses to analgesic therapies.

The NIDCR recognizes these sex and gender aspects of pain and encourages the submission of applications that take these factors into consideration in studies of the comorbidities associated with TMJD.

Inquiry

Specific questions about this Notice should be directed to:

John W. Kusiak, PhD
Molecular and Cellular Neuroscience Program
National Institute of Dental and Craniofacial Research
45 Center Drive, Room 4AN12J
Bethesda, MD 20892
Telephone: 301-594-7984
Fax: 301-480-8319
Email: [email protected]