NIDCD CLINICAL RESEARCH CENTER GRANTS (P50)

Release Date:  November 30, 2000 (see NOT-DC-03-004)

NOTICE:  DC-01-001

National Institute on Deafness and Other Communication Disorders

The National Institute on Deafness and Other Communication Disorders 
(NIDCD) announces a new Clinical Research Center Grant (P50) program. 
These guidelines supercede all prior guidelines for the NIDCD Multiple 
Project Center/Program Project/Clinical Center Grants (P50/P01). The 
NIDCD made substantive revisions to their program project (P50/P01) 
programs in 1999, as well as adding the Core Center (P30) grant 
mechanism. After experience with these changes, the NIDCD has made 
additional changes to the way it supports multiple project center 
grants. In summary, the main changes include: 1) the requirement that 
the research conducted on a P50 be clinical in nature, and 2) the 
removal of the requirement that subprojects must be interdependent.

The NIDCD will use Clinical Research Center grants (P50) to support 
clinical research (i.e., research involving individuals with disorders 
or data/tissues derived from individuals with disorders to study a 
disorder of human communication; examples of such research include, but 
are not limited to, studies of the prevention, pathogenesis, 
pathophysiology, diagnosis, treatment, management or epidemiology of a 
disease or disorder of hearing, balance, smell, taste, voice, speech, or 
language). Non-human research is precluded on an NIDCD P50 grant and 
humans without communication disorders may participate in the research 
only when normal controls are needed. The four essential criteria for 
the new P50 are: 
1. The research to be conducted must be clinical (see above for 
definition).
2. The P50 must have a well-defined central unifying theme consisting 
of three or	more subprojects with supporting cores as appropriate.
3. Each subproject must be unambiguously related to the central 
unifying theme.
4. The P50 must be multidisciplinary.

The NIDCD believes that most research within its mission areas can be 
best accomplished via the investigator-initiated individual research 
grant (R01) and the research core center grant (P30) mechanisms. There 
are special circumstances in clinical research, however, that warrant 
the use of the P50 mechanism. Additional information may be obtained 
from NIDCD staff listed below or may be found on the NIDCD web site: 
http://www.nidcd.nih.gov/funding/types/p30_2003.pdf.

SUBMISSION OF APPLICATIONS 
Applications will be accepted under these new guidelines beginning with 
the February 1, 2001 application receipt date. New (Type 1) applications 
prepared using the previous NIDCD Multiple Project Center (P50) Grant 
Guidelines (http://www.nidcd.nih.gov/funding/types/p50/table_b.asp) 
will be accepted only through the February 1, 2001 deadline. 
Applications that have already been submitted under the previous 
guidelines will continue through initial and secondary review and 
revisions will be allowed. All applications received after the February 
1, 2001 submission deadline must be responsive to the new guidelines. 
Applicants with pending applications are urged to contact the Program 
Administrator with whom they have been working for more information.

STAFF CONSULTATION 
Inquiries about P50 applications should be directed to one of the NIDCD 
Program Administrators listed below.

HEARING: 
Dr. Amy Donahue
E-mail: amy_donahue@nih.gov 
Dr. Nancy Freeman
E-mail: nancy_freeman@nih.gov
Dr. Thomas Johnson
E-mail: thomas_johnson@nih.gov 
Dr. Lynn Luethke
E-mail: lynn_luethke@nih.gov 
BALANCE: 
Dr. Daniel Sklare
E-mail: daniel_sklare@nih.gov 
SMELL/TASTE: 
Dr. Barry Davis
E-mail: barry_davis@nih.gov
VOICE/SPEECH/LANGUAGE
Dr. Judith Cooper
E-mail: judith_cooper@nih.gov 

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