Notice of Intent to Publish a Funding Opportunity Announcement for Justice Community Overdose Innovation Network - Phase II Research Hubs (U01 Clinical Trial Required)
Notice Number:

Key Dates

Release Date:
August 21, 2023
Estimated Publication Date of Notice of Funding Opportunity :
August 21, 2023
First Estimated Application Due Date:
February 12, 2025
Earliest Estimated Award Date:
August 01, 2025
Earliest Estimated Start Date:
September 01, 2025
Related Announcements

August 21, 2024 - HEAL Initiative: Justice Community Overdose Innovation Network (JCOIN) - Phase II Methodology and Advanced Analytics Resource Center (UM1 Clinical Trial Not Allowed). See RFA-DA-24-068

August 21, 2024 - HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Coordination and Translation Center (U2C Clinical Trial Optional). See RFA-DA-24-069

Issued by

National Institute on Drug Abuse (NIDA)


The National Institute on Drug Abuse intends to promote a new initiative by publishing a notice of funding opportunity (NOFO) to seek applications for research hubs to participate in Phase II of the Justice Community Overdose Innovation Network (JCOIN).

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The NOFO is expected to be published in Fall 2024 with an expected application due date in Winter 2025.

Details of the planned NOFO are provided below.

Research Initiative Details

HEAL Initiative

This NOFO is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed the development and implementation of scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information and periodic updates about the HEAL Initiative is available at:


The Justice Community Overdose Innovation Network (JCOIN) has two broad, complementary goals: to build the evidence base for the delivery of substance use disorder (SUD) treatment services for individuals involved in the criminal-legal system, and to build capacity to implement effective services in both criminal-legal and treatment settings. Phase I of JCOIN established a consortium of practitioner-partnered research projects focused primarily on testing strategies to connect individuals to evidence-based opioid use disorder (OUD) treatment at key transition points between the criminal-legal system and the community. Phase I supported 13 multi-site clinical trials and more than 50 additional distinct research protocols including surveys, modeling, dissemination, and pilot studies, supplements, and ancillary projects. The Network was supported by a Coordination and Translation Center (CTC) and a Methodology and Advanced Analytics Resource Center (MAARC).

Given recent evolution of both the epidemiology of the overdose crisis and public policy intended to support overdose prevention efforts, new research is needed to take effective interventions to scale in jails, courts, and community corrections, and to rigorously test new and emerging models for effectively addressing the complex needs of individuals with SUD and/or high overdose risk at earlier points of the sequential intercept model.

JCOIN Phase II will consist of three highly integrated components: Research Hubs that will each execute multi-site implementation or effectiveness trials in one or more segments of the criminal-legal system; a Coordination and Translation Center, which will provide logistical support, capacity building, national stakeholder engagement, and broad dissemination of research results; and a Methodology and Advanced Analytics Resource Center, which will provide a wide array of data and analytic support services.

A NOFO using a cooperative agreement mechanism is anticipated to support JCOIN Phase II Research Hubs in conducting new research projects in the following areas of priority interest:

  • Multi-site hybrid effectiveness-implementation trials on SUD services or treatment linkages delivered at early intercept points (e.g., 911/crisis response calls; overdose response teams; police diversion/deflection programs).
  • Multi-site implementation research trials with the goal of scaling up evidence-based interventions in criminal-legal systems (prisons, jails, probation/parole, courts) across states or regions.
  • Studies to develop and test interventions to address stigma toward addiction, addiction treatments, and persons involved in the criminal-legal system.
  • Research to create, adapt, and implement technological tools to facilitate continuity of care during transitions between carceral settings and the community.
  • Observational studies, natural experiments, or other rigorous designs to assess the implementation and impacts of emerging policies (e.g., state implementation of 1115 waivers) on the delivery of SUD treatment to individuals with criminal-legal system involvement.

Research Hubs will be expected to participate in Steering Committee and workgroup activities to support the collective governance of the Network and facilitate cross-hub collaborations and pilot studies.

Funding Information

Estimated Total Funding

$20,000,000 in total costs in FY25

Expected Number of Awards


Estimated Award Ceiling

$1,500,000 in direct costs per year

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time.


Please direct all inquiries to:

Carrie Mulford
National Institute on Drug Abuse (NIDA)
Telephone: 301-827-6473