Notice of Information: Research Opportunity Announcements for the Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain
Notice Number:

Key Dates

Release Date:

June 2, 2023

Related Announcements


Issued by

National Institute on Drug Abuse (NIDA)

National Center for Advancing Translational Sciences (NCATS)

Office of The Director, National Institutes of Health (OD)


The Office of the Director, National Institutes of Health, the National Institute on Drug Abuse, and the National Center for Advancing Translational Sciences intend to publish Research Opportunity Announcements (ROAs) to support Phase I of the Native Collective Research Effort to Enhance Wellness (N CREW) Program: Addressing Overdose, Substance Use, Mental Health, and Pain. ROAs may be issued to solicit applications to support:

  1. Tribes and Native American Serving Organizations (T/NASOs) to develop and pilot research projects and increase research capacity and infrastructure to conduct research related to the NIH Helping End Addiction Long-term (HEAL) Initiative; and   
  2. the provision of real-time resources, wrap-around technical assistance, partnership support, and other activities to enhance research capacity and infrastructure within T/NASOs and accelerate progress on N CREW goals. 

The ROAs are expected to be published in June 2023 and should be available via and the NIH Helping to End Addiction Long-term (HEAL) Initiative N CREW website:

This Notice is being provided to allow potential applicants time to prepare for the publication of the ROAs. 

Visit the N CREW website for all up-to-date information about the program, and email to engage with N CREW NIH staff and/or to submit questions about the N CREW program or forthcoming ROAs.

This Notice does not commit the Government to fund other transaction awards. This Notice is for informational purposes only. It is not a formal ROA, Notice of Funding Opportunity (NOFO), or Broad Agency Announcement (BAA). Do not submit any proposals or applications to this Notice. All information contained in this Notice is subject to change at any time. 

Research Initiative Details

The N CREW Program is part of the NIH’s HEAL  Initiative, which aims to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to (1) improve prevention and treatment for opioid misuse and addiction and (2) enhance pain management. More information about the HEAL Initiative is available at:

The N CREW Program is anticipated to include two phases, with an estimated budget of approximately $268 million over a 7-year period for all elements of the Program. The forthcoming ROAs are expected to solicit applications for only Phase I of the N CREW Program. NIH intends to allocate up to $25 million across approximately two years (FY24 and FY25) to fund approximately 20 awards in Phase I, which will include planning, development, and piloting of research and/or data improvement projects led by T/NASOs and wraparound, real-time technical assistance, resources, training, and coordination in support of those activities.

Applications are not being solicited at this time. 


Please direct all inquiries to:

Dr. Kathy Etz
National Institute on Drug Abuse (NIDA)