April 30, 2021
PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-20-184 - NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
PA-20-200 - NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PAR-18-437 - Cutting-Edge Basic Research Awards (CEBRA) (R21-Clinical Trial Optional)
PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)
RFA-DA-22-006 - High-throughput Discovery and Validation of Novel Signal Transducers or Small Molecules that Modulate Opioid or other Substance Use Disorder Relevant Pathways (R01 - Clinical Trials Not Allowed)
National Institute on Drug Abuse (NIDA)
The purpose of this notice is to encourage research project submissionsthat leverage whole-brain or large connectome resources in genetically tractable model organisms to investigate the role of distributed neuronal circuits in behaviors relevant to substance use disorders (SUD).
In 2018 the BRAIN 2.0 Advisory Committee to the Director (ACD) recommended that NIH should “consider applying methods developed in model systems towards understanding neuropsychiatric disease states at the circuit level – as well as seeking to understand ancestral principles governing circuit operation shared across phylogeny and evolution.” This NOSI intends to direct this recommendation towards NIDA-related basic research.
Historically, animal research in the substance use field has relied mainly on rats and non-human primates to “model” the effects of drugs on human behavior. Expansion into the use of mice, because they are genetically tractable, together with the emergence of genetic tools that target cells with specificity, revolutionized the field by allowing for more precise monitoring and manipulation of brain circuits. However, the field has not taken full advantage of the many other genetically tractable non-mammalian organisms, such as drosophila, zebrafish and C.elegans. The modest size of their nervous system and transformative connectome resources generated in recent years have positioned these model systems as unparalleled choices for the systematic investigation of distributed neuronal circuits underlying behavioral repertoires relevant to substance use.
Example of resources relevant to this NOSI:
Combining the use of such resources with the unique biological features or specific behaviors of model organisms affords the power of evolutionary biology to reveal conserved fundamental principles within behavioral domains.
Example of behavioral domains relevant to this NOSI:
Example of research topics relevant to this NOSI:
Application and Submission Information
This notice applies to due dates on or after June 5, 2021 and subsequent receipt dates through September 8, 2024.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.