Notice Number: NOT-DA-20-031
Release Date: February 6, 2020
First Available Due Date: June 5, 2020
Expiration Date: January 8, 2023
PA-19-056: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-19-091: NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
PA-19-052: NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
PA-19-053: NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)
PAR-19-278: Exploiting Genome or Epigenome Editing to Functionally Validate Genes or Variants Involved in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed)
National Institute on Drug Abuse (NIDA)
The purpose of this Notice is to inform potential applicants to the National Institute on Drug Abuse (NIDA) of special interest in research examining transcriptomic, genomic, epigenomic, regulatory RNA, nuclear organization, or functional genomics to better understand Substance Use Disorder (SUD)-related biological processes.
Dependence on addictive substances, including opioids, prescription drugs, nicotine, methamphetamine, cannabis, stimulants, and inhalants, is a major public health problem. Candidate genes or genetic/epigenetic variants involved in SUDs have been identified using human or animal genome-wide association scans, QTL characterization, gene expression profiling, forward or reverse genetic screens, or through transcriptomic, epigenomic, regulatory RNA or proteomic analyses. Genes and variants identified by these methods are priority targets for functional validation and further mechanistic characterization.
Applicants may propose to identify, validate, and/or characterize genes, genetic or epigenetic variants, chromatin or nuclear features, or other molecular phenotypes associated with SUD-relevant biological processes or behaviors. It is anticipated that successful projects in this area will help us better understand the neurobiological mechanisms underlying SUDs and may also provide foundational knowledge to advance future SUD prevention, diagnosis, or therapeutic efforts. Applicants are encouraged to leverage the use of existing genetic resources whenever possible.
A gene or variant could manifest itself phenotypically at the level of a molecular pathway, cell, circuit, organism, or social interaction, leading to phenotypic differences in protein function, cell morphology, neural connectivity, behavioral responses to an addictive substance, or behavioral responses to social cues. NIDA encourages studies at any of these levels to identify phenotypic differences relevant to addictive processes and further elucidate the driving molecular pathways that converge to elicit biobehavioral changes. Applications through this NOSI may vary greatly in depth and breadth of analysis. For example, they may investigate a single high priority epigenetic or genetic variant in detail (e.g. using gene editing approaches) or test several hundred genes/variants rapidly (e.g. using high throughput RNA knockdown).
NIDA seeks to understand addiction to substances such as opioids, prescription drugs, nicotine, methamphetamine, cocaine, and cannabis. Applicants should therefore focus on one or more NIDA-relevant addictive substances. Applicants proposing to investigate alcohol in concert with one or more NIDA-relevant addictive substances may also submit their application through this NOSI.
Research interests include, but are not restricted to, the following:
Application and Submission Information
This notice applies to due dates on or after June 5, 2020 and subsequent receipt dates through January 8, 2023.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
PA-19-052 NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
PA-19-053 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PA-18-591 Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)
PAR-19-278 Exploiting Genome or Epigenome Editing to Functionally Validate Genes or Variants Involved in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed)
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Financial/Grants Management Contact(s)
National Institute on Drug Abuse (NIDA)