Notice Number: NOT-DA-20-020
Release Date: February 24, 2020
First Available Due Date: June 05, 2020
Expiration Date: September 08, 2023
PA-19-056: NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-19-052: NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
PA-19-053: NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp - Clinical Trial Optional)
PA-19-055: NIH Research Project Grant (Parent R01 Clinical Trial Required)
PA-19-091: NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
National Institute on Drug Abuse (NIDA)
The purpose of this NOSI is to encourage applications that explore and/or test the role of gene networks in substance use disorders (SUD) through the development, optimization, and/or implementation of multilevel computational, bioinformatics, statistical and/or analytical approaches that integrate at least two levels of data (e.g. genomic, epigenomic, chromatin, environmental, etc.).
Many genetic loci, genetic pathways, epigenetic factors, and environmental conditions contribute to SUD. Recent large-scale ‘omics studies have uncovered an emerging repertoire of single nucleotide variants, copy number variants, gene expression changes and epigenetic alterations associated with SUD-relevant biological processes or behaviors. These studies underscore the complexity of the genetic/epigenetic architecture of SUD. They also highlight that the lack of analytical tools to tease out gene networks, gene x gene interactions, and the contributions of multi-level data comprises a major gap in understanding how these different types of data contribute to the pathophysiology and neurobiological causes of SUD.
Applicants may propose to create, use, and/or optimize bioinformatics tools, computational methods, and/or other statistical methods and analytics tools to integrate multi-level data that detect the gene networks involved in SUD. Studies should incorporate at least two types of data relevant to gene network analyses that address SUD-relevant biological processes or behaviors. SUDs of interest include those involving include: nicotine, cocaine, methamphetamine, opioids, cannabinoids, or combinations of these drugs. Applicants proposing to investigate alcohol in concert with one or more NIDA-relevant substances may also submit their application to this NOSI.
Studies may propose to collect new data or analyze data from previous studies. Possible types of data include (but are not limited to): genetic, epigenetic, molecular, proteomic, metabolomic, circuit-level molecular analyses, and/or environmental studies. As applications will span different disciplines (e.g. expertise in SUD-relevant phenotypes and behaviors, ‘omics, bioinformatics, computational biology, statistical analysis, and big data analytics, applicants are encouraged to assemble multidisciplinary teams that span the expertise required for successful completion of the project. Applicants should create open source databases, software, standards, platforms, etc. whenever possible and adhere to privacy and ethics concerns. All data should adhere to FAIR principles (e.g. findable, accessible, interoperable, and reusable) to enable secondary analyses by the scientific community. Projects should leverage the use of existing genetic resources whenever possible. Applicants should include strategies to test and confirm the findings for reproducibility and relevance to research on substance use disorders.
Research interests include, but are not limited to applications that propose to:
Applications nonresponsive to terms of this NOSI will be not be considered for the NOSI initiative. Applications that are not responsive include:
Application and Submission Information
This notice applies to due dates on or after June 5, 2020 and subsequent receipt dates through September 8, 2023.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions: