Notice Number: NOT-DA-20-005
Release Date: March 3, 2020
First Available Due Date: June 05, 2020
Expiration Date: September 08, 2023
PAR-19-368 (R01) Accelerating the Pace of Drug Abuse Research Using Existing Data (Clinical Trial Optional)
PA-19-054 (Parent R21) NIH Exploratory/Developmental Research Grant Program (Clinical Trial Required)
PA-19-053 (Parent R21) NIH Exploratory/Developmental Research Grant Program (Clinical Trial Not Allowed)
PA-19-092 (Parent R21) NIH Exploratory/Developmental Research Grant Program (Basic Experimental Studies with Humans Required)
PA-19-056 (Parent R01) Research Project Grant (Clinical Trial Not Allowed)
PA-19-055 (Parent R01) Research Project Grant (Clinical Trial Required)
PA-19-091 (Parent R01) NIH Research Project Grant (Basic Experimental Studies with Humans Required)
National Institute on Drug Abuse (NIDA)
This Notice invites innovative research to characterize the consequences of psychosocial factors on mechanisms of action and determinants of vulnerability and/or resilience to substance use disorder (SUD). Research using basic or clinical approaches is appropriate.
Psychosocial stress – or stress induced by situations of social threat or inequity (e.g., low socioeconomic status, childhood trauma) – has repeatedly been linked to substance use disorders (SUDs). Neighborhood poverty and social support are shown to influence substance use patterns. Among smokers, multiple psychosocial stressors are associated with relapse, and acute psychosocial stress has been demonstrated to enhance cigarette craving and smoking behavior. Similarly, psychosocial stress has been associated with greater risk of relapse in individuals with alcohol and cocaine use disorders.
Recent findings suggest that neurocognitive substrates pertinent to SUD are not only influenced by chronic psychosocial stress, particularly early life adversity, but also by acute stressors. Further, factors such as social support are seen to positively influence outcomes at various points in the substance use trajectory. However, the underlying mechanisms of these and other psychosocial factors, especially in the context of SUD, remain poorly understood. Taken together, the extant literature suggests that mechanistic investigations of SUDs need to be conceptualized with consideration to the underlying psychosocial factors. The goal of this Notice of Special Interest (NOSI) is to promote research directed at elucidating the neurobiological mechanisms by which psychosocial factors during different windows of development shape the trajectory of substance use and substance use disorder.
NIDA seeks applications that support mechanistic research on psychosocial factors related to the substance use trajectory.
Research questions include but are not limited to:
Application and Submission Information
This notice applies to due dates on or after June 5, 2020 and subsequent receipt dates through September 8, 2023.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Vani Pariyadath, Ph.D.
NIDA/Division of Neuroscience and Behavior