HEAL Initiative: Request for Administrative Supplements to Existing Grants to Accelerate Research on Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16-30)

Notice Number: NOT-DA-19-003

Key Dates
Release Date: December 10, 2018
Response Date: February 01, 2019

Related Announcements

Issued by
National Institute on Drug Abuse (NIDA)


The National Institute on Drug Abuse (NIDA) announces the opportunity for investigators with relevant active research project grants and cooperative agreements to submit administrative supplements, according to PA-18-591 Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional), for funded projects to inform development of interventions and strategies to prevent opioid misuse and opioid use disorder (OUD) in high-risk older adolescents and young adults (ages 16-30). In response to the opioid epidemic and as part of the NIDA HEAL initiative, Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16–30), the Prevention Research Branch in the Division of Epidemiology, Services and Prevention Research will support administrative supplements to existing grant awards for research on and to inform interventions and approaches for preventing opioid misuse and OUD in high-risk older adolescents and young adults. This announcement is for one-year administrative supplements to support research that will contribute to knowledge needed to inform development of prevention approaches, particularly those tailored to individual or subgroup characteristics, to address the opioid crisis. Studies using novel methods (e.g., systems science, network science, computational methods, simulation modeling) are encouraged. To be considered for funding, all administrative supplement requests must be submitted no later than February 1, 2019.

Examples of potential research areas include, but are not are not limited to:  

  • Research to increase knowledge about specific risk factors and pathways for initiation of opioid misuse and escalation to OUD. This may include the use of existing data to study gaps in knowledge about risk factors and pathways to initiation of use/misuse.
  • Studies that propose to examine whether interventions that target substance use and misuse and other outcomes are effective for preventing initiation of non-medical opioid use, opioid misuse, escalation to OUD, and initiation of injection drug use.
  • Studies that leverage data and infrastructure of existing grants to conduct modeling of existing data or conduct simulations on opioid-related topics to inform development, implementation and impact of prevention interventions and strategies.
  • Extension of intervention content and activities to include strategies relevant to opioids.
  • Studies that add opioid-relevant measures and outcomes.
  • Studies that increase the sample to include populations at-risk for opioid misuse and OUD.
  • Research to include settings relevant for identifying, accessing, engaging, and intervening with populations at-risk and facilitating linkage to prevention interventions/services (e.g., in health care settings, justice settings, American Indians/Alaska Natives reservations, or other settings as justified by the applicant).
  • Extension of existing studies by adding measures, analysis or extending the sample to identify unique risk factors for opioid misuse and OUD, targets for intervention, and inform prevention interventions and strategies for high risk populations highly impacted by the opioid crisis, including American Indians/Alaska Natives (AI/AN) and rural.
  • Studies to identify and address barriers and promote facilitators to the implementation of interventions to prevent opioid misuse and OUD

The work proposed should be within the scope of the existing award. Before submitting, grantees are strongly encouraged to contact the program official for their grant award to discuss whether the proposed supplement is within scope of the existing award. Applications should include a detailed description of the proposed activities and a justification that the proposed work is within the scope of the existing award. Applications should also demonstrate adequate progress to date on the parent study.

The activities proposed in the supplement must be able to be accomplished within the current competitive segment. No-cost extensions will not be granted to permit the submission of a supplement request. 


Requests must reflect the actual needs of the proposed projects. Administrative supplements will be awarded for FY19 funding only and the project and budget periods must be within the currently approved project period for the existing parent award. Administrative Supplement requests should be for no more than $250,000 Total Costs. 

NIDA staff will review the application and consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research. The parent grant must remain active for the entire period of the supplemental funding. Administrative supplement requests above $100,000 in direct costs will also be reviewed by the National Advisory Council on Drug Abuse.

Applicants should begin the supplement application abstract by stating “This application is being submitted in response to NOT-DA-19-003", to assist in identifying supplements submitted to this notice.

Submitting your administrative supplement request:  Applicants should submit to  PA-18-591, Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional), which details three ways to submit your request. 

To be considered for funding, all administrative supplement requests must be submitted no later than February 1, 2019.


Please direct all inquiries to:

Jacqueline Lloyd, PhD, MSW 
National Institute on Drug Abuse (NIDA) 
Telephone: 301-443-8892 
Email: lloydj2@mail.nih.gov