Notice Number: NOT-DA-18-023
Release Date: June 29, 2018
Response Date: July 20, 2018
This RFI is for information and planning purposes only, and should not be construed as a solicitation or an obligation on the part of the Federal Government, the National Institutes of Health (NIH), or the National Institute on Drug Abuse (NIDA). The NIH does not intend to make any awards based on responses to this RFI or to otherwise pay for the preparation of any information submitted or for the Government's use of such information.
Terminology: This RFI is focused on the use, misuse, abuse of opioids and Opioid Use Disorders (OUD). Opioids include prescription and illicit opioids, such as heroin, illicitly manufactured fentanyl, and related analogs. Opioid Use Disorder (OUD) refers to the clinical diagnosis defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).
Problem Statement: Despite the availability of multiple effective evidence-based interventions and practices, most Americans at risk for or suffering from an OUD do not receive appropriate prevention and treatment services. Simultaneously, opioid overdose rates continue to increase.
NIDA, in partnership with SAMHSA, is exploring options for conducting a multi-site national research effort in up to three communities to develop and test approaches for the systematic implementation and sustainability of an integrated set of evidence-based interventions across healthcare, behavioral health, justice systems, state and local governments, and community organizations to prevent and treat opioid misuse and OUD. The goals are to decrease fatal and non-fatal overdoses, decrease the incidence of OUD and related infectious diseases (e.g. Hepatitis C and HIV), increase the number of individuals receiving medication-assisted treatment (MAT), increase the proportion retained in treatment beyond 6 months, and increase the number of individuals receiving needed recovery support services. This research would be a part of the NIH Helping to End Addiction Long-term (HEAL) Initiative (https://www.nih.gov/research-training/medical-research-initiatives/heal-initiative).
Information Requested: This RFI solicits input from the extramural research community and public stakeholders. NIDA and SAMHSA especially seek input on study elements such as, but not limited to:
Target metrics feasible for outcomes, candidate outcomes could include, but are not limited to those listed above: rates of non-fatal and fatal overdose; prevalence and incidence of opioid misuse, OUD and Hepatitis C; percent of patients screened for opioid misuse and OUD and who received a brief intervention or were referred to treatment; percent of patients initiated on MAT and retained in medication treatment beyond 6 months; rates of naloxone distribution and overdose reversals; opioid analgesic and benzodiazepine prescription rates; and implementation of prevention programs
Integrated Evidence-based Interventions:
Infrastructure, Partnerships, Collaboration:
How to Submit a Response:
Responses will be accepted until July 20, 2018 , via e-mail to: OpioidRFI@nida.nih.gov. Please mark your responses with the RFI identifier NOT-DA-18-023 Responses are expected to be no longer than approximately 2000 words.
Respondents will receive an automated e-mail confirmation acknowledging receipt of their response but will not receive individual feedback.
Any identifiers (e.g. names, institutions, e-mail addresses, etc.) will be removed when responses are compiled. Only the processed, anonymized results will be shared internally with NIDA and NIH program staff and participating leadership across the Department of Health and Human Services, as appropriate. Nonetheless, no proprietary information should be submitted.
Please direct all inquiries to: