Notice of Intent to Publish a Funding Opportunity Announcement for Basic Mechanisms of Brain Development for Substance Use and Dependence (R01)

Notice Number: NOT-DA-17-004

Key Dates
Release Date:  December 5, 2016

Estimated Publication Date of Announcement:  January 2017 
First Estimated Application Due Date:  February 2017 
Earliest Estimated Award Date:   September 2017
Earliest Estimated Start Date:  November 2017

Related Announcements

Issued by
National Institutes on Drug Abuse (NIDA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)


The National Institutes on Drug Abuse (NIDA), with National Institute on Alcohol Abuse and Alcoholism (NIAAA), intends to reissue a Funding Opportunity Announcement (FOA) to solicit applications for research on the developing brain or brain areas that play significant roles in mediating emotional and motivated behavior and in substance use and dependence.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in January 2017 with an expected application due date in February 2017.

This FOA will utilize the R01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This initiative supports basic neuroscience research into the cellular and molecular mechanisms of brain development.  Of particular interest are the brain areas and circuits that mediate the euphoric properties of abused substances, as well as how exposure to substances of abuse affects the cellular and molecular mechanisms underlying the development of the neural circuits relevant to rewarding properties of substance abuse and addiction. Vertebrate model systems (such as rat, mouse, chick, frog, zebrafish and non-human primates) provide insights into mechanisms of development on formation and specification of brain areas and neural circuits, while invertebrate systems (such as Drosophila and C. elegans) are likely to provide unique information on developmental processes and molecular mechanisms.  In addition, human sample based experimental approaches using emerging and advancing technologies, such as induced pluripotent stem cells, mini-brain and organoid cultures, and tissue chip technologies, are encouraged for the studies of teratogenesis, neural differentiation and migration, neural circuit initiation and formation, and cytotoxicity of substances of abuse. Therefore, approaches using these or other model systems both in vitro and in vivo are highly relevant to this program announcement.  In addition, investigators are encouraged to analyze developmental mechanisms that contribute to sexual dimorphisms in substance abuse and addiction and/or in any other psychiatric disorders relevant to substance abuse and addiction.



Please direct all inquiries to:

Da-Yu Wu, PhD
National Institute on Drug abuse (NIDA)
Telephone: 301-435-4649