Notice of Intent to Publish a Funding Opportunity Announcement for A Longitudinal Study of Adolescent Brain and Cognitive Development (ABCD) Research Sites (U01)

Notice Number:


Key Dates

Release Date: November 26, 2014

Estimated Publication Date of Announcement: January 2015

First Estimated Application Due Date: April 2015

Earliest Estimated Award Date: September 2015

Earliest Estimated Start Date: September 2015

Related Announcements



Issued by

National Institute on Drug Abuse (NIDA)

National Cancer Institute (NCI)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


NIDA and the following NIH Institutes and Centers (ICs), NIAAA, NICHD, NCI intend to publish a Collaborative Research on Addiction at NIH (CRAN) funding opportunity announcement to solicit applications for research project sites to establish a national, multisite, multi-modal, longitudinal cohort study to prospectively examine the neurodevelopmental and behavioral effects of substance use from early adolescence (approximately age 9-10) through the period of risk for substance use and substance use disorders. The primary objective of this initiative is to design and implement a study that can address the following overarching research questions: (1) What is the impact of diverse patterns of substance use on the structure and function of the developing brain? (2) What are the consequences of substance use on physical health, psychosocial development, cognition (e.g., information processing, learning, memory, decision making), academic achievement, motivation, emotional regulation, and other behaviors? (3) How does substance use affect the expression (e.g., onset, course, severity) of psychopathology, including substance use disorders, and how does the emergence of psychopathology influence substance use? (4) What factors (e.g., prenatal exposure, genetic, epigenetic, neurobiological, demographic, psychosocial, familial, ecological) influence the trajectories of substance use and its consequences? (5) In what ways does the use of specific substances contribute to the use of other substances (so-called gateway interactions)?

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations, identify program faculty, and create responsive applications.

The FOA is expected to be published in January 2015 with an expected application due date in April 2015.

This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This initiative solicits linked, individual research project sites from a group of investigators (both within and across institutions) whose scientific and technical expertise will allow them to address the research questions described above. Each research project site could be a single institution or it could be formed as a central hub institution with other institutions as spokes to the hub. In either organizational setup, the Program Director(s)/Principal Investigator(s) will have overall responsibility.

This FOA will run in parallel with companion FOAs that solicit applications for a Coordinating Center and a Data Analysis and Informatics Center. All consortium components (individual research project sites, a data analysis and informatics center, and a coordinating center) must be linked and coordinated at the time of submission, with each application originating from the Program Director(s)/Principal Investigator(s) research institution. It is expected that investigators upon funding will work jointly with federal staff at NIDA, NCI, NIAAA, and NICHD to achieve study goals.



Please direct all inquiries to:

Kevin P. Conway, Ph.D.
National Institute on Drug Abuse (NIDA)
Telephone: 301-402-1817

John A. Matochik, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-451-7319