STRUCTURAL BIOLOGY OF MEMBRANE PROTEINS (PA-02-060)   ADDENDUM

Release Date:  February 21, 2002

NOTICE:  NOT-DA-02-004

National Institute on Drug Abuse (NIDA)
 (http://www.nida.nih.gov)

PURPOSE

This addendum is to program announcement (PA) PA-02-060, which was 
released in the NIH Guide for Grants and Contracts on February 11, 2002 
at http://grants.nih.gov/grants/guide/pa-files/PA-02-060.html.  
This PA is intended to support research on the structure of membrane 
proteins at atomic resolution.  This addendum adds the National 
Institute on Drug Abuse (NIDA) as a participating institute in this 
program announcement.

The NIDA is interested in furthering the understanding of membrane 
protein receptors and transporters, their structure, and their 
interaction with ligands relevant to drug abuse research.  These 
proteins include:  the cannabinoid CB1 and CB2 receptors, the vanilloid 
receptor, the orphanin receptor, the mu, delta, and kappa opioid 
receptors, the neuronal nicotinic receptor subtypes, the NMDA receptor 
complex, the metabotropic glutamate receptors I-III, the GABA-A 
receptor, and the dopamine, serotonin, and norepinephrine transporters 
and any other neuropeptide receptors that are affected by drugs of abuse. 

Applicants are encouraged to develop techniques to express, solubilize, 
purify, and stabilize these receptors and transporters, and to obtain 
structural information (diffraction, NMR, microscopy) on single 
particles or crystals, as described in the PA.

The following are NIDA contacts:

Direct inquiries regarding programmatic issues to:

Rao Rapaka, Ph.D.
Paul Hillery, Ph.D.
Division of Neuroscience and Behavioral Research
National Institute on Drug Abuse
6001 Executive Boulevard   Room 4282, MSC 9555
Bethesda, MD  20892-9555
Telephone:  (301)-443-6275
Fax:  301-594-6043
E-mail:  ph44x@nih.gov

Direct inquiries regarding fiscal matters to:

Gary Fleming, J.D., M.A.
Grants Management Branch
National Institute on Drug Abuse
6001 Executive Boulevard, Room 3158, MSC 9541
Bethesda, MD  20892-9541
Telephone:  (301)-443-6710
E-mail:  gf6s@nih.gov

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