Notice of Intent to Publish a Funding Opportunity Announcement for The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:
July 07, 2022
Estimated Publication Date of Funding Opportunity Announcement:
August 31, 2022
First Estimated Application Due Date:
November 07, 2022
Earliest Estimated Award Date:
July 03, 2023
Earliest Estimated Start Date:
July 03, 2023
Related Announcements


Issued by

National Cancer Institute (NCI)


The National Cancer Institute (NCI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite U01 cooperative agreement applications that apply systems-level approaches to tackle questions in metastasis that will integrate with and complement ongoing research in the Metastasis Research Network (MetNet). Successful U01 Research Projects will join the MetNet.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in late summer 2022 with an expected application due date in fall 2022. This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into metastasis and metastatic processes to begin to consider applying for this new FOA.

The MetNet is a collection of Research Centers that support using systems-level approaches to understand the non-linear, dynamic, and emergent processes in metastasis. Considering chronological progression and biological scales, the MetNet seeks to collectively derive a more comprehensive and cohesive picture of metastasis as a whole body, systems-level problem.

This upcoming FOA will invite U01 cooperative agreement applications for MetNet Research Projects. These Research Projects should be defined, discrete entities that use systems-level approaches to address gaps and opportunities in metastasis research that will integrate with and complement ongoing research within the MetNet Centers.

Collaborative investigations combining expertise from metastasis, cancer biology, engineering, systems biology, physiology, and physical oncology fields are encouraged and these investigators should also begin considering applying to this FOA.

Among the areas of research encouraged by this initiative are themes of early dissemination and crosstalk as they apply to metastasis from the lung, prostate, pancreas, liver, kidney, bladder, or ovary; metastasis to sites such as the bone or lung or rare sites; and associated metastatic processes such as the establishment of, maintenance of, or emergence from dormancy. Investigations that explore mechanisms of metastasis in cancers with rising mortality rates and those with high incidence in diverse populations are highly encouraged.

Funding Information


Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling

$500,000 per year direct costs

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Joanna M. Watson, Ph.D.

National Cancer Institute (NCI)