Notice of Intent to Publish a Funding Opportunity Announcement for Research to Understand and Address the Survivorship Needs of Individuals Living with Advanced Cancer (R01 Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
April 08, 2022
Estimated Publication Date of Funding Opportunity Announcement:
May 27, 2022
First Estimated Application Due Date:
September 01, 2022
Earliest Estimated Award Date:
July 01, 2023
Earliest Estimated Start Date:
July 30, 2023
Related Announcements


Issued by

National Cancer Institute (NCI)


The National Cancer Institute (NCI) intends to publish a Funding Opportunity Announcement (FOA) as a Request for Applications (RFA) to solicit applications that support innovative observational and interventional research studies that address knowledge gaps pertaining to the survivorship needs of individuals living with likely incurable cancers.

This Notice of Intent to Publish (NOITP) is being provided to allow potential applicants time to develop responsive projects and meaningful collaborations.

The FOA is expected to be published in Spring 2022 with an expected first application due date in September, 2022.

The intended RFA will utilize the R01 (clinical trial optional) mechanism. Details of the planned RFA are provided below.

Research Initiative Details

As used in this announcement and in the intended RFA, the phrase ‘individuals living with likely incurable cancer’ includes both those persons who are diagnosed with advanced cancer that is likely incurable and those persons who are diagnosed with or progress to metastatic cancer. The needs of these survivors likely differ from cancer survivors diagnosed with and treated for early-stage disease; however, many of these needs have not been systematically documented or effectively managed. The goal of this FOA is to enhance observational and interventional efforts to better understand and address the survivorship needs of individuals living with likely incurable cancers.

Applications submitted to the intended RFA can include any group of individuals living with likely incurable cancer (e.g., any cancer type or diagnosed at any age). Proposed studies may focus on the survivor, the survivor-caregiver dyad, or the survivor-provider dyad as long as outcomes (or mechanisms) relevant to the survivor are examined. Applications that focus on individuals living with likely incurable cancer who are treated with newer therapies (e.g., immunotherapies, biotherapies) are of strong interest. Applications that include diverse populations based on race/ethnicity, geography, or other socioeconomic factors are encouraged.

Examples of relevant research topics include but are not limited to:

  • Identification of factors associated with physical and psychological symptoms (including symptom trajectories), adverse effects, and other survivorship outcomes among individuals living with likely incurable cancer
  • Understanding the impact of living longer with likely incurable cancer on employment and financial concerns, given changing care trajectories and delivery of innovative, often more costly, treatments
  • Development and testing of models of survivorship care for individuals living with likely incurable cancer that can be tailored based on the needs of the survivor and health system resources that include attention to management of changing symptom trajectories, psychosocial support, care coordination, management of comorbid conditions, and/or support for the survivor/caregiver dyad
  • Development of interventions to address shared decision-making in the context of prognostic awareness for individuals living with likely incurable cancer

Funding Information


Estimated Total Funding

Up to $3M in FY2023 and $3.5M in FY2024

Expected Number of Awards


Estimated Award Ceiling

$500,000 Direct Costs per year for a total of five years.

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Michelle Mollica, PhD, MPH, RN, OCN

National Cancer Institute (NCI)


Lisa Gallicchio, PhD

National Cancer Institute (NCI)