Key Dates
NOT-CA-22-074 - Notice of Intent to Publish a Funding Opportunity Announcement for Cancer Adoptive Cellular Therapy Network (Can-ACT) for Adult Cancers (UG3/UH3 Clinical Trial Required)
NOT-CA-22-075 - Notice of Intent to Publish a Funding Opportunity Announcement for Cancer Adoptive Cellular Therapy Network (Can-ACT) for Pediatric Cancers (UG3/UH3 Clinical Trial Required)
National Cancer Institute (NCI)
The National Cancer Institute (NCI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) soliciting applications for a Coordinating Center for the Cancer Adoptive Cellular Therapy (Can-ACT) Network. The Can-ACT network of research sites will advance collaborative and novel approaches for adoptive cell therapy for solid tumors, with an emphasis on the transition from preclinical testing and translational studies to early phase clinical trials. The Coordinating Center will provide leadership to the Can-ACT network, facilitate data sharing and collaboration, and coordinate clinical trial activities between research sites and the NCI.
This notice is being provided to allow potential applicants sufficient time to develop a responsive grant application. The FOA is expected to be published in July 2022 with an expected application due date in September 2022. Details of a planned pre-application webinar will be announced in the Guide after publication of the FOA. This FOA will utilize the U24 activity code.
This Notice encourages investigators with expertise and insights into the area of adoptive cell therapy clinical trials for the treatment of cancer to begin to consider applying for this new FOA.
Clinical trials conducted through Can-ACT will be supported by the Immune Cell Network Core Facility (ICN Core) at the Frederick National Laboratory for Cancer Research (FNLCR). The ICN Core will provide GMP capabilities for molecularly modifying immune cells, producing vectors, and standardizing cell characterization assays for clinical testing, as well as supporting the collection and harmonization of multi-site clinical trial data. The Coordinating Center for Can-ACT will primarily be responsible for organizing efforts between clinical trial sites and the ICN Core.
The Coordinating Center will also provide leadership to the Can-ACT network by:
- Organizing meetings for the research sites;
- Forming a Steering Committee for the Can-ACT network;
- Establishing an External Advisory Committee; and
- Providing overall guidance for the further development of the ICN Core and Can-ACT Network.
TBD
$500,000 in total costs
1
$225,000 direct costs per year
93.395
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government
Applications are not being solicited at this time.
Please direct all inquiries to:
Kasia Bourcier, Ph.D.
National Cancer Institute (NCI)
202-657-7589
Email: [email protected]
Laura Hunter, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-5344
Email: [email protected]
and Human Services (HHS)
