Notice of Intent to Publish a Funding Opportunity Announcement for Global Implementation Science for Equitable Cancer Control (GlobalISE Cancer Control) (U54 Clinical Trials Optional)
Notice Number:

Key Dates

Release Date:
February 15, 2022
Estimated Publication Date of Funding Opportunity Announcement:
June 25, 2022
First Estimated Application Due Date:
September 25, 2022
Earliest Estimated Award Date:
May 30, 2023
Earliest Estimated Start Date:
July 01, 2023
Related Announcements


Issued by

National Cancer Institute (NCI)


The National Cancer Institute (NCI) intends to issue a Funding Opportunity Announcement (FOA) as an RFA (i.e., Request for Applications) for the GlobalISE Cancer Control Consortium (U54 Clinical Trial Optional). This RFA aims to support global implementation science in low- and middle-income countries (LMICs). This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Details of the planned RFA are provided below.

Research Initiative Details

The purpose of the Global Implementation Science for Equitable Cancer Control (GlobalISE Cancer Control) RFA is to build research capacity for implementation science in low- and middle-income countries (LMICs) and to stimulate research on approaches to identify, understand, and overcome barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based cancer control interventions in LMICs. Cancer control interventions can include programs, tools, policies, and guidelines that have been empirically demonstrated to improve health.

Applicants must be from, or partner with, an LMIC-based institution. Applicants are required to propose two implementation research projects and develop two cores: an administrative/engagement core and a research capacity-building core. The administrative/engagement core will oversee the award and foster productive collaboration between researchers and key stakeholders in the LMIC setting (including practitioners and health system leaders) throughout all phases of the award. The research capacity-building core will provide training and structured mentorship in implementation science for LMIC researchers and practitioners.

This RFA aims to encourage transdisciplinary teams of researchers and implementers to develop and test implementation strategies that may be applicable across a diverse range of contexts and populations. Studies should be designed to rigorously assess implementation outcomes (e.g., acceptability, adoption, appropriateness, feasibility, fidelity, costs, penetration, sustainability) of the strategies under study. Impactful implementation science typically involves and benefits from interdisciplinary collaboration from a variety of fields. Some of these fields include but are not limited to global health, anthropology, epidemiology, systems science, organizational and management theory, economics, individual and systems-level behavioral change, engineering, and marketing. Applicant teams should include investigators that provide the necessary expertise to inform the research aims.

Additionally, this RFA seeks to develop research capacity for sustained implementation research through structured mentoring programs within LMIC-based academic institutions, clinical, and community sites.

Examples of relevant research topics include but are not limited to:

  • Studies on measuring and tracking adaptations to enhance the adoption and integration of cancer control interventions (e.g., cancer prevention, screening, detection, diagnosis, treatment, and survivorship) in the proposed LMIC-based clinical and community setting(s).
  • Studies to understand, develop, and test strategies to efficiently bundle cancer control services (e.g., multiple cancer control interventions).
  • Studies to understand, develop, and test strategies to effectively integrate cancer control into primary care and other care settings.
  • Studies to understand, develop, and test strategies to de-centralize cancer control services to community settings.
  • Studies to develop and test strategies to enhance retention across the continuum of cancer care in fragmented systems.

The centers funded through this consortium will work together to share research methods and measures, train U.S. and LMIC investigators in implementation science, and engage with implementers across community and health systems.

Funding Information


Estimated Total Funding

Up to $4 million in FY 2023

Expected Number of Awards


Estimated Award Ceiling

$500,000 Direct Costs per year for a total of five years.

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
U.S. Territory or Possession
Non-domestic (non-U.S.) Entity (Foreign Organization)
Eligible Agencies of the Federal Government

Applications are not being solicited at this time.


Please direct all inquiries to:

Gila Neta, Ph.D.

National Cancer Institute (NCI)