Notice of Intent to Publish a Funding Opportunity Announcement for Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
January 25, 2022
Estimated Publication Date of Funding Opportunity Announcement:
May 08, 2022
First Estimated Application Due Date:
June 16, 2022
Earliest Estimated Award Date:
October 01, 2022
Earliest Estimated Start Date:
November 30, 2022
National Cancer Institute (NCI)
The National Cancer Institute (NCI) intends to reissue a Funding Opportunity Announcement (FOA) to solicit applications for dissemination and implementation (D&I) research in health. This FOA is intended to be a re-issuance of PAR-19-275, Dissemination and Implementation Research in Health (R21 Clinical Trial Optional), which will expire May 8, 2022, following the May 7, 2022 AIDS Application Due date. The re-issuance FOA will be published on May 8, 2022, and the D&I Program will continue without interruption and R21 Research Project Grant applications will be accepted on Standard Application Due date(s) of June 16, 2022, and thereafter.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
Details of the planned FOA are provided below.
Research Initiative Details
The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (herein referred to collectively as evidence-based interventions). Studies that promote equitable dissemination and implementation of evidence-based interventions among underrepresented communities are encouraged. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (“de-implement”) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. Applications that focus on re-implementation of evidence-based health services (e.g., cancer screening) that may have dropped off amidst the ongoing COVID pandemic are encouraged.
Examples of relevant research topics include but are not limited to:
- Studies on culturally tailored implementation strategies to enhance the adoption and integration of health promotion, prevention, screening, early detection, and diagnostic interventions, as well as effective treatments, clinical procedures or guidelines into existing care systems.
- Studies on the implementation of multiple evidence-based interventions within community or clinical settings (including community clinics, FQHCs, and primary care clinics) to meet the needs of complex patients and diverse systems of care.
- Longitudinal and follow-up studies on the factors that contribute to the sustainability of evidence-based interventions in public health and clinical practice.
- Studies testing dissemination or implementation strategies to eliminate health disparities and improve quality of care in underserved populations (based on their racial or ethnic group, religion, socioeconomic status, gender, age, mental health, cognitive, sensory or physical disability, sexual orientation or gender identity, geographic location (place/context) or other characteristics historically linked to discrimination or exclusion).
- Studies conducting comparative economic evaluations of implementation strategies in a variety of settings and across phases of implementation.
- Studies on measuring and tracking adaptations to evidence-based interventions and implementation strategies over time.
- Studies on scaling-up evidence-based implementation strategies.
- Studies on reducing or stopping ("de-implementing") the use of clinical and community practices that are ineffective, unproven, low-value, or harmful.
- Studies on the relationship of context, including but not limited to the role of social determinants of health or social needs, and local capacity of clinical and community settings to adoption, implementation, and sustainability of evidence-based practices.
- Prospective or retrospective studies of the adoption, implementation, and sustainability of health policies and their interaction with programs and contextual factors.
- Studies of influences on the creation, packaging, transmission, and reception of evidence for effective health interventions.
- Studies of strategies to impact organizational structure, climate, culture, and processes to enable dissemination and implementation of clinical/public health information and effective clinical/public health interventions.
- Studies on the development of study designs, research methods, and analytic approaches for studying dissemination and implementation.
- Studies that focus on the testing of theories, models, and frameworks for D&I processes.
- Studies on developing and validating reliable D&I relevant outcome and process measures.
- Studies on developing and validating pragmatic and actionable measures to guide selection, continuation, and discontinuation of implementation strategies over time.
- Studies on developing and strengthening tools and techniques for conducting rapid and rigorous qualitative data collection and analysis, including approaches for comparisons of qualitative data across implementation contexts appropriate for accelerated implementation timelines.
- Studies on policies and other contextual factors that influence the success of dissemination or implementation efforts.
- Studies on collecting and sharing multi-level qualitative and quantitative D&I-related data.
Studies that examine policy implementation, specifically the implementation and dissemination of health care and public health policies across federal, state, local and organizational policies.
Expected Number of Awards
Estimated Award Ceiling
The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.
Primary Assistance Listing Number(s)
Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
For-Profit Organization (Other than Small Business)
Indian/Native American Tribal Government (Federally Recognized)
Independent school districts
U.S. Territory or Possession
Non-domestic (non-U.S.) Entity (Foreign Organization)
Eligible Agencies of the Federal Government
Applications are not being solicited at this time.
Please direct all inquiries to:
National Cancer Institute (NCI)