June 17, 2021
National Cancer Institute (NCI)
The National Cancer Institute (NCI) Pediatric Immunotherapy Network is seeking broad input and feedback from sources of expertise and interest in pediatric immunotherapy. This request for information (RFI) is part of a planning effort designed to recognize current research gaps, identify promising opportunities, and develop strategies for successfully advancing novel pediatric immunotherapy approaches to clinical testing.
The Pediatric Cancer Working Group of the NCI Cancer Moonshot Blue Ribbon Panel identified pediatric immunotherapy as a priority for the acceleration of research advances for childhood cancers. The Pediatric Immunotherapy Discovery and Development Network (PI-DDN) was established by the NCI to discover and characterize new targets for immunotherapies, design experimental models to test the effectiveness of pediatric immunotherapies, develop new pediatric immunotherapy treatments, and improve the understanding of tumor immunity in children and adolescents with cancer. Over the years, there have been major advances in applying immunotherapy approaches to childhood cancers, as illustrated by the high rate of sustained complete responses in children with refractory leukemia using anti-CD19 chimeric antigen receptor (CAR) engineered T cells and by the improvement in survival for children with high-risk neuroblastoma using an anti-GD2 chimeric monoclonal antibody. However, for most patients with high-risk or refractory childhood cancers, there are no effective immunotherapy options, and the immunotherapy approaches being advanced for adult cancers based on high tumor mutational burden appear to have limited relevance for most childhood cancers.
All stakeholders with an interest in improving the treatment of childhood cancers through the application of immunotherapy approaches are invited to provide information. Your response may mention your membership or affiliation within an industry, government, or academia.
NCI is seeking information that includes, but is not limited to, perspectives on the following areas:
Submitting a Response
All responses must be submitted to firstname.lastname@example.org by July 10, 2021. Please include the Notice Number "NOT-CA-21-086" in the subject line. Response to this RFI is voluntary. Responders are free to address any or all the categories listed above. Please do not include any proprietary, classified, confidential, or sensitive information in your response.
All individual responses will remain confidential. Any identifiers (e.g., names, institutions, e-mail addresses, etc.) will be removed when responses are compiled. Only the processed, anonymized results will be shared internally with NIH staff members and members of scientific working groups convened by the NCI, as appropriate.
The NIH will use the information submitted in response to this RFI at its discretion and will not provide comments to any responder's submission. The collected information will be reviewed by NIH staff, may appear in reports, and may be shared publicly on an NIH website.
The Government reserves the right to use any non-proprietary technical information in summaries of the state of the science, and any resultant solicitation(s). The NIH may use the information gathered by this RFI to inform the development of future funding opportunity announcements.
This RFI is for information and planning purposes only and should not be construed as a solicitation or as an obligation on the part of the Federal Government, the National Institutes of Health (NIH), or individual NIH Institutes and Centers. No basis for claims against the U.S. Government shall arise as a result of a response to this request for information or from the Government’s use of such information.