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NOT-CA-21-075 - Notice of Intent to Publish a Funding Opportunity Announcement for Pancreatic Ductal Adenocarcinoma (PDAC) Stromal Reprogramming Consortium (PSRC) (U01 Clinical Trial Not Allowed)

National Cancer Institute (NCI)

The purpose of this Notice is to announce the NCI's intention to issue a Funding Opportunity Announcement (FOA) that invites applications for a PSRC Coordinating and Data Management Center (CDMC) that will support research projects and activities to enhance and facilitate the mission of PSRC as a whole.

his Notice is being provided to allow potential applicants sufficient time to develop a responsive, multicomponent PSRC CDMC proposal.

The FOA is expected to be published in Summer 2021 with an expected application due date in Fall 2021. Details of the planned pre-application webinar will be announced in the Guide after publication of the FOA.

This FOA will use the U24 (Resource-Related Research Projects - Cooperative Agreements) activity code. Details of the planned FOA are provided below.

It is anticipated that the research projects and resource cores of the individual PSRC U01 Research Projects will generate data, unique biospecimens, resources, models, and technologies that require a dedicated CDMC to centralize, integrate, and manage inter- and intra-network data, material, and know-how exchange. The PSRC CDMC will function as a coordinating intermediary across the network as a whole and facilitate liaisons between PSRC Research Projects, NCI staff, and the cancer research community.

The principal functions of the PSRC CDMC are to: 1) facilitate the integration of the multicomponent PSRC activities and communications; 2) support and enhance collective PSRC findings; and 3) accelerate iteration of discoveries between basic/mechanistic and preclinical/translational cancer research. It is envisioned that the PSRC CDMC will have national leadership and impact in addressing unmet needs to facilitate PDAC progression and therapy resistance research.

PSRC activities to be supported include, but are not limited to:

• Facilitating communication and meeting coordination (e.g., steering committee, topical interest groups, collaboration meetings);
• Assisting and building accessibility to infrastructure, technology, and support platforms for multimodal data management and integration;
• Providing statistical and computational support for analysis and comprehension of data;
• Establishing guidelines for rigor, standards, harmonization, and interoperability of data;
• Serving as an outreach vehicle to interface with NCI staff and the larger basic and translational cancer research community
• Assistance in the NCI’s productivity evaluation of the PSRC;

Applications are not being solicited at this time.

Please direct all inquiries to:

Peter Ujhazy, MD, PhD
Division of Cancer Treatment & Diagnosis
National Cancer Institute (NCI)
Telephone: 240-276-5686
Email: [email protected]