April 13, 2021
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Drug Abuse (NIDA)
National Institute of Neurological Disorders and Stroke (NINDS)
The 2017 Nobel Prize in Physiology or Medicine was awarded for the discoveries of molecular mechanisms controlling circadian rhythms; highlighting the fundamental importance of the field. Since then, the renascence of circadian research has been seen in many biomedical research fields, from basic biology to chronobiological therapeutic applications. Circadian rhythms are a fundamental biological phenomenon that involves daily changes in the cellular environment in all living organisms entrained with their environment. They play a critical role in many aspects of human health and diseases across the lifespan. The master clock located in the suprachiasmatic nucleus of the hypothalamus orchestrates the coordination of peripheral clocks in almost all organs to maintain the homeostasis of daily physiological processes. The clock genes and the molecular mechanisms that self-regulate a negative feedback loop controlling the circadian rhythms were identified more than 20 years ago. Research has shown that the homeostasis or disruption of circadian rhythm and sleep is involved in many physiological or pathophysiological aspects of human health and disease, from metabolism, microbiome, neuronal and immune function to cancer, obesity, metabolic syndrome, aging, Alzheimer disease, pain, neurological disease, behavior disorder, and mental health.
Chronotherapy practice has been used by some medical physicians and practitioners for decades as a complementary and integrative medicine practice. The discovery of the molecular mechanistic principles for biological clock gene regulation has widespread and profound implications for the role of the circadian clock in health, disease development, and therapeutic outcome. The understanding of circadian-mediated mechanism of health and disease are critical in moving circadian science and principles of circadian rhythm regulation into medicine for the prevention, management and treatment of disease. Delineating the links between the biological clock, diseases, and disease therapeutics is a timely research opportunity.
The purpose of this Request for Information (RFI) is to gain feedback, comments, and novel ideas from the members of scientific communities in the United States (U.S.) and abroad as well as from persons representing other segments of the American public as listed below to help identify the needs and priorities in this area of science, and plan future activities and initiatives that can most significantly enhance the research in circadian-based medicine (chronomedicine) including new therapeutic targets and greater benefit of the biomedical research community contributing to the precision medicine.
We are requesting input from the scientific community as well as from persons representing other segments of the American public as listed above on the challenges and research needs in this field that can best be addressed through a concerted and coordinated effort to enhance research and development of circadian-based medicine or chronomedicine. Specifically, respondents are asked to briefly address the following aspects:
Responses will be accepted through May 7, 2021
Note: Do not include any proprietary or confidential information.
If you are willing to do so, please indicate your primary affiliation/role from the categories listed below:
How to Submit a Response
Respondents will receive an automated e-mail confirmation acknowledging receipt of their response but will not receive any individualized feedback. The NIH will use all information submitted in response to this RFI Notice at its discretion and will not provide comments to any responder�s submission. The NIH may use information gathered by this RFI Notice to inform the development of future funding opportunity announcements and/or in any resultant solicitations.
This RFI Notice is for information and planning purpose only and should not be interpreted as a solicitation or as an obligation on the part of the Federal Government, the NIH, NCI, NIDA, NINDS and/or the NHLBI. No monetary awards will be made to pay for the preparation of any information submitted or for the Government�s use of such information. No basis for claims against the U.S. Government shall arise as a result of a response to this request for information or from the Government�s use of such information.
Dan Xi, Ph.D.
National Cancer Institute (NCI)