Notice of Intent to Publish a Funding Opportunity Announcement for New Cohorts to Assess Environmental Exposures and Cancer Risk (UG3/UH3 Clinical Trial Optional)
Notice Number:

Key Dates

Release Date:
July 24, 2020
Estimated Publication Date of Funding Opportunity Announcement:
November 01, 2020
First Estimated Application Due Date:
January 29, 2021
Earliest Estimated Award Date:
September 15, 2021
Earliest Estimated Start Date:
September 15, 2021
Related Announcements

NOT-CA-20-091 - Notice of Intent to Publish a Funding Opportunity Announcement for Coordinating Center for New Cohorts to Assess Environmental Exposures and Cancer Risk (U24 Clinical Trial Not Allowed)

Issued by

National Cancer Institute (NCI)


The National Cancer Institute (NCI) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for innovative scientific research to address knowledge gaps between environmental exposures and cancer etiology across diverse populations using new prospective cohort studies, which will be facilitated by a Coordinating Center that is expected to be awarded under a separate RFA (see the parallel notice of intent to publish announcement NOT-CA-20-091). The Cohorts for Environmental Exposures and Cancer Risk (CEECR) will provide scientific evidence related to environmental exposures and cancer risk. The CEECR will be supported through UG3/UH3 phased awards.

Approximately five new prospective cohorts are expected to be awarded. Applicants are encouraged to be innovative in their assessments of exposure as well as in study design. Techniques employed should be accurate, reproducible, and relevant to the proposed scientific aims. This initiative calls for research questions that can be addressed in both the short-term and longer-term with an observational study design.

This Notice is being provided to allow potential applicants time to develop responsive projects and meaningful collaborations.

The FOAs are expected to use the UG3/UH3 mechanism for CEECR (Clinical Trials Not Allowed).

The FOA is expected to be published in November 2020 with an expected application due date in January 2021.

Details of the planned FOAs are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of environmental exposures and cancer risk to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise in environmental epidemiology including environmental health science, exposure assessment tools and methods, cancer epidemiology, toxicology, molecular epidemiology, statistics, and community engagement will be encouraged, and these teams of investigators should also begin considering applying for this FOA.

Among the areas of research encouraged in this initiative are epidemiologic research examining the impact of environmental exposures on markers of carcinogenesis and cancer risk, as well as research designed to improve the translation of existing knowledge of strategies for the prevention of cancer.

This Funding Opportunity Announcement (FOAs) solicits applications for:

  • Prospective observational research studies to address environmental exposures and cancer risk (UG3/UH3).

The new cohorts for environmental exposures and cancer risk (CEECR) (UG3/UH3 phased awards) will be supported by a Coordinating Center (U24; NOT-CA-20-091).

The presentation of this initiative to the NCI Board of Scientific Advisors (BSA) can be accessed at this link:

Funding Information
Estimated Total Funding

Up to $6.5 million in fiscal year (FY) 2021 for new cohorts.

Expected Number of Awards

Five UG3/UH3 awards.

Estimated Award Ceiling

$6.5 million total costs per year for new cohorts.

Primary CFDA Numbers

93.393; 93.399

Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Somdat Mahabir, Ph.D., M.P.H.

National Cancer Institute (NCI)


Abee Boyles, Ph.D.
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-3241

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices