Notice Number: NOT-CA-20-032
Release Date: March 20, 2020
First Available Due Date: May 15, 2020
Expiration Date: May 16, 2020
NOT-CA-22-057 - Notice of Special Interest (NOSI): Administrative Supplement Opportunity to Stimulate or Strengthen Global Cancer Health Disparities Research.PA-18-591, Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Cancer Institute (NCI)
This Notice of Special Interest informs current awardees that the National Cancer Institute (NCI) is providing the opportunity for supplemental funding to stimulate interest and promote the inclusion of global (outside of the United States [U.S.]) populations, biospecimens and/or data to enhance/accelerate the progress in understanding and reducing cancer health disparities in the U.S. and globally. This Administrative Supplement is designed to support NCI-funded investigators to add global populations, biospecimens, and/or data to their currently funded projects and thereby strengthen their current research aims to better advance cancer health disparity research.
U.S. racial/ethnic minority and/or underserved populations continue to experience significant disparities in cancer risk and outcomes despite the many advancements in cancer research. For instance, African Americans have the highest death rates from all cancer sites combined, and from cancers of the lung, colon and rectum, breast, prostate, and the cervix of all racial/ethnic groups in the U.S. American Indians and Alaska Natives have the poorest 5-year survival rates among all racial/ethnic groups, for all cancers combined. While Asian Americans and Pacific Islanders have lower rates for most common cancers compared to other racial/ethnic groups, they have the highest rates for liver cancer. Similarly, Hispanic women have lower rates for many common cancers but their rates for new diagnoses of cervical cancer is higher than all other populations. The causes of these cancer health disparities are multifactorial, including differences in access to healthcare, diet and lifestyle, cultural barriers, environmental exposures, and ancestry-related biologic/genetic factors.
The landscape of the U.S. racial/ethnic minority populations, especially Hispanics/Latinos, Asian Americans and African Americans, continues to be transformed by foreign-born Hispanics, Asians and Blacks, many of whom originate from low- and middle-income countries (LMICs) in Latin America (Mexico, Central and South America), Southeast Asia, the Caribbean, and Africa. Preliminary research shows that there are differences in health seeking behaviors, risk behaviors and health outcomes between U.S.-born racial/ethnic minorities and their foreign-born counterparts; and that these differences might be attributed, in part, to the environmental, biological/genetic, and sociocultural differences. The changing demographics and dynamics among racial/ethnic minority populations in the U.S., and the complexity of cancer health disparities globally underscore the need for innovative, multilevel, and collaborative global research to better understand and address cancer health disparities. Expanding cancer health disparities research to include global populations, biospecimens and/or data will advance/accelerate the progress in understanding and addressing cancer health disparities in the U.S. and globally.
Specific Areas Research Interest
The NCI encourages supplement research projects that employ comparative research designs between global populations and at least one of the U.S. racial/ethnic minority populations (e.g., American Indian/Alaska Native, Asian, African American, Native Hawaiian/Pacific Islander, and Hispanic/Latino populations) or underserved populations. Areas of research where inclusion of global populations, biospecimens and/or data might enhance/accelerate the progress in understanding and reducing cancer health disparities include, but are not limited to the following:
The NCI encourages collaborative research among NCI-funded domestic investigators and their foreign counterparts who have complementary expertise and access to global populations, biospecimens, and/or data. Applicants are encouraged to leverage existing resources and partnerships, and to design projects that can reasonably be completed within the given time and budget. Within the scope of the award (i.e., the peer reviewed and awarded project/program and specific aims, studies enhanced by supplemental funding may involve the collection and/or analysis of samples and/or data from previous studies. Where appropriately justified, supplemental funding may be applied towards attaining adequate sample sizes and/or increasing population diversity to advance global cancer health disparities research.
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
Administrative Review Process:
NCI will conduct administrative reviews of applications submitted to their IC and will support the most meritorious applications submitted for consideration, based upon the programmatic priorities and availability of funds.
Applicants are strongly encouraged to notify the program contact at the Institute supporting the parent award that a request has been submitted in response to this NOSI to facilitate efficient processing of the application.
Applications nonresponsive to the terms and conditions will be not be considered for this NOSI initiative.
Please direct all inquiries to:
James R. Alaro, Ph.D.
Center for Global Health
National Cancer Institute (NCI)