EXPIRED
Notice Number: NOT-CA-20-022
Key Dates
Release Date: January 15, 2020
First Available Due Date: May 07, 2020
Expiration Date: January 08, 2023
PA-19-056 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
PA-19-053 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
PAR-20-052 NCI Small Grants Program for Cancer Research for Years 2020, 2021, and 2022 (NCI Omnibus R03 Clinical Trial Optional)
PAR-20-030 HIV-associated Non-Communicable Diseases Research at Low- and Middle-Income Country Institutions (R21 Clinical Trial Optional)
Issued by
National Cancer Institute (NCI)
Purpose
The purpose of this Notice of Special Interest (NOSI) is to continue advancing our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS), particularly the non-AIDS defining malignancies which are now a leading cause of death in HIV-infected individuals. Research efforts that identify specific contributions of HIV infection and its potential interaction with other pathogens towards the development and pathogenesis of these cancers and provide information on the clinical outcomes of such cancers in the HIV-infected population are sought. Ultimately, such efforts could inform screening approaches and therapies targeted to the HIV-infected population.
High or medium priority AIDS research as described in NOT-OD-15-137 is encouraged in areas such as the study of the etiologic factors, cofactors, immunopathogenesis, diagnosis, and consequences of both non-AIDS defining and AIDS-defining malignancies in populations with an underlying HIV infection.
Background
Past and current progress in the development of treatments and understanding the molecular mechanisms of Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) infection has greatly improved patient survival. However, increased survival has been accompanied by the development of cancer at a higher rate in treated individuals than that observed in the HIV/AIDS negative population. During the early days of the AIDS epidemic the most frequently reported AIDS-defining malignancies were Kaposi’s sarcoma (KS) and Non-Hodgkin lymphoma (NHL). Now with increased survival as a result of widespread use of antiretroviral therapy (ART), non-AIDS defining cancers (i.e., anal, skin, and lung cancers, and Hodgkin’s disease) are on the increase in HIV infected populations.
The topics chosen for this NOSI are aligned with relevant areas of emphasis described in the NIH Office of AIDS Research (OAR) FY 2019/2020 NIH Strategic Plan for HIV and HIV-Related Research. As a priority area, the 2019/2020 NIH Plan includes the need to address HIV-Associated Comorbidities, Coinfections, and Complications. Assessing the impact of malignancies and understanding their pathogenesis in HIV-infected patients is of high priority.
Research Objectives
NCI continues to seek research that advances our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying HIV infection. Research that addresses high or medium priority AIDS research in areas such as etiologic factors, coinfections, cofactors, immunopathogenesis, diagnosis, and consequences of both non-AIDS defining and AIDS-defining malignancies in populations with an underlying HIV infection is sought in response to this NOSI.
Note: Topics considered low priority AIDS in NOT-OD-15-137 are not appropriate for this NOSI. Basic research in tumors caused by KSHV is, for the moment, being considered as high priority AIDS and will be eligible for funding under this NOSI. All applications considered for funding will be reviewed by OAR and must be aligned with the priorities in NOT-OD-15-137.
This NOSI encourages, but is not limited to, research applications in the following areas:
Application and Submission Information
This notice applies to due dates on or after May 7, 2020, and subsequent receipt dates through January 8, 2023.
Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcements through the expiration date of this notice. Although the National Cancer Institute (NCI) is not listed as a Participating Organization in all the FOAs listed below, applications for this initiative will be accepted.
All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:
Inquiries
Please direct all inquiries to:
Scientific/Research Contacts
Elizabeth Read-Connole, Ph.D. (for basic science research)
National Cancer Institute, NIH
Telephone: 240-276-6190
Email: bconnole@mail.nih.gov
Geraldina Dominguez, Ph.D. (for research on malignant complications of HIV/AIDS)
National Cancer Institute (NCI)
Telephone: 301-496-3204
Email: domingug@mail.nih.gov
Johnan Kaleeba, Ph.D. (for research on malignant complications of HIV/AIDS)
National Cancer Institute (NCI)
Telephone: 240-781-3420
Email: johnan.kaleeba@nih.gov
Vaurice Starks (for epidemiologic research and digital epidemiology)
National Cancer Institute (NCI)
Telephone: (301) 624-1299
Email: starksv@mail.nih.gov
Mukesh Verma, Ph.D. (for research on epigenetics in the topic area)
National Cancer Institute (NCI)
Telephone: 240-276-6889
Email: mv66j@nih.gov
Peer Review Contact(s)
Examine your eRA Commons account for review assignment and contact information (which appears 2 weeks after the submission/receipt due date).
Financial/Grants Management Contact
Mutema Nyankale
National Cancer Institute (NCI)
Telephone: 240-276-5987
Email: nyankalem@mail.nih.gov