Notice of Intent to Publish: Funding Opportunity Announcement for Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

Notice Number: NOT-CA-19-038

Key Dates

Release Date: March 28, 2019
Estimated Publication Date of Funding Opportunity Announcement: May 08, 2019
First Estimated Application Due Date: June 05, 2019
Earliest Estimated Award Date: October 01, 2019
Earliest Estimated Start Date: November 30, 2019

Related Announcements

Issued by
National Cancer Institute (NCI)


The National Cancer Institute (NCI) intends to reissue a Funding Opportunity Announcement (FOA) to solicit applications for dissemination and implementation (D&I) research in health.

This FOA is intended to be a re-issuance of PAR-18-007, Dissemination and Implementation Research in Health (R01 Clinical Trial Optional), which will expire May 8, 2019, following the May 7, 2019 AIDS Application Due date.

The re-issuance FOA will be published on May 8, 2019, and the D&I Program will continue without interruption and R01 Research Project Grant applications will be accepted on Standard Application Due date(s) of June 5, 2019, and thereafter.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Details of the planned FOA is provided below.

Research Initiative Details

The purpose of this Funding Opportunity Announcement (FOA) is to support innovative approaches to identifying, developing, testing, evaluating and/or refining strategies to disseminate and implement evidence-based practices (e.g. behavioral interventions; prevention, early detection, diagnostic, treatment and disease management interventions; quality improvement programs) into public health, clinical practice, and community settings. Conversely, there is a benefit in understanding circumstances that create a need to “de-implement” or reduce the use of strategies and interventions that are not evidence-based, have been prematurely widely adopted, yield sub-optimal benefits for patients, or are harmful or wasteful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged.

Examples of relevant research directions include but are not limited to:

  • Studies of strategies to implement health promotion, prevention, screening, early detection, and diagnostic interventions, as well as effective treatments, clinical procedures or guidelines into existing care systems.
  • Studies of the implementation of multiple evidence-based practices within community or clinical settings to meet the needs of complex patients and diverse systems of care.
  • Studies of the local adaptation of evidence-based practices in the context of implementation that systematically identify intervention components that surpass or fall short of expected intervention effects.
  • Longitudinal and follow-up studies on the factors that contribute to the sustainability of evidence-based interventions in public health and clinical practice.
  • Studies testing the effectiveness and cost-effectiveness of dissemination or implementation strategies to reduce health disparities and improve quality of care among rural, minority, low literacy and numeracy, and other underserved populations.
  • Studies of the de-implementation of clinical and community practices that are not evidence-based, have been prematurely widely adopted, yield sub-optimal benefits for patients, or are harmful or wasteful.
  • Studies of the relationship of context and local capacity of clinical and community settings to adoption, implementation and sustainability of evidence-based practices.
  • Prospective or retrospective studies of the adoption, implementation and sustainability of health policies and their interaction with programs and contextual factors.
  • Studies of influences on the creation, packaging, transmission and reception of valid health research knowledge.
  • Studies of systems interventions to impact organizational structure, climate, culture, and processes to enable dissemination and implementation of clinical/public health information and effective clinical/public health interventions.
  • Studies that focus on the development and testing of theoretical and evaluation models for D&I processes.
  • Development of D&I relevant outcome and process measures and suitable methodologies for dissemination and implementation approaches.
  • Studies of the dissemination of varied strategies to promote effective patient and caregiver communication, leading to improved healthcare delivery and outcomes.
  • Studies of the dissemination and implementation of effective and cost-effective strategies for incorporating genomic medicine, sequence-based diagnostics and therapeutics in clinical care.
  • Studies testing the implementation and use of genomic information, family history risk information, and/or pharmacogenetic information for improved diagnosis and treatment.

Funding Information

Estimated Total Funding TBD
Expected Number of Awards TBD
Estimated Award Ceiling TBD
Primary CFDA Numbers 93.393

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Small Business
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
City or township governments
Special district governments
Independent school districts
U.S. Territory or Possession
Non-domestic (non-U.S.) Entity (Foreign Organization)
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Gila Neta, Ph.D.
National Cancer Institute (NCI)

David Chambers, D.Phil.
National Cancer Institute (NCI)
Telephone: 240-276-5090