NCI Participation in PAR-18-694, Interdisciplinary Research Teams to Investigate Reciprocal Basic Behavioral and Social Linkages Between Sleep and Stress (R24 - Clinical Trial Optional)

Notice Number: NOT-CA-18-066

Key Dates
Release Date: April 13, 2018

Related Announcements

Issued by
National Cancer Institute (NCI)


The purpose of this Notice is to inform potential applicants that the National Cancer Institute (NCI) is participating in PAR-18-694, "Interdisciplinary Research Teams to Investigate Reciprocal Basic Behavioral and Social Linkages Between Sleep and Stress (R24 - Clinical Trial Optional)."

The following changes have been made to reflect NCI's participation in this FOA:

Part 1. Overview Information

Components of Participating Organizations

Division of Program Coordination, Planning, and Strategic Initiatives, Office of Behavioral and Social Sciences Research (OBSSR)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. OBSSR may co-fund applications assigned to those Institutes/Centers.

National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute on Drug Abuse (NIDA)
National Cancer Institute (NCI)

Catalog of Federal Domestic Assistance (CFDA) Number(s)
93.273; 93.846, 93.279, 93.399

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

The text that follows this sentence is hereby to be considered as information inserted at the end of the original Funding Opportunity Description in Part 2, Section I, of PAR-18-694, just before the final sentence that states "See Section VIII. Other Information for award authorities and regulations."

In addition to research areas already listed in the Funding Opportunity Description, NCI is interested in applications that address important gaps in this area, including applications that:

Explore how the interaction between sleep and stress affects health behaviors, decision-making, and/or health outcomes across the spectrum of cancer control. “Sleep” may refer to changes in sleep duration (sleep deprivation, sleep restriction), timing (e.g., circadian misalignment), and/or quality. Areas of interest to the NCI that would be appropriate to this FOA include, but are not limited to:

  • How do sleep and stress interact to influence levels of cancer-related biomarkers (e.g., immune function)? And how do these interactions change across the cancer spectrum?
  • How do sleep and stress combine to lead to poor health behaviors that increase an individual’s cancer risk?
  • What are the common mechanisms (e.g., self-regulation) through which sleep and stress interact with other cancer-related behaviors?
  • What are the genetic predictors of the relationship between sleep and stress as cancer-related behaviors or risk factors?
  • How do environmental, socioeconomic, racial/ ethnic, or cultural factors modulate the interaction of stress levels and sleep that influence cancer-related behaviors?
  • How do sleep deprivation and the stress of being a cancer patient affect treatment decisions and adherence to treatment plans?
  • What is the interaction between cancer treatments, sleep deprivation, and stress, and how does this affect cognitive function and quality of life?
  • How does the interaction sleep deprivation and stress change across the trajectory of cancer survivorship?
  • What are the critical periods during the course of cancer diagnosis and treatment when managing stress and/or minimizing sleep disruption can maximize psychosocial functioning/coping, follow-up to screening, and/or treatment adherence among patients?
  • How do sleep and stress affect the relationship between cancer patients/survivors and their partners/caregivers?
  • How do psychological factors and social resources (e.g., chronic emotion regulatory strategies, social support, optimism, resilience) contribute to trajectories of stress, sleep, and related outcomes among cancer patients/ survivors?
  • Through what strategies are stress and sleep co-regulated at the dyadic level (e.g., among spouse dyads or parent-child dyads), and what co-regulation strategies contribute to better treatment decision making, adherence, and cancer outcome trajectories?
  • How do multi-level factors (e.g., genetic, psychological, environmental) interact to influence cancer risk via stress and sleep?
  • How do sleep and stress interact to affect the outcome of cancer treatments?
The R24 grant mechanism is designed to build research infrastructure and incorporates research projects as part of this effort. NCI is interested in projects thatshould bring together teams of investigators with diverse expertise who can, collectively, provide new insights into the relationships between aspects of sleep and stress across the cancer continuum. NCI is interested in supporting projects that To address research aims, projects may include components such as the development of research networks, training, research and administrative cores, data repositories (for project and public use), as well as formative or pilot data which can be used to inform future, larger transdisciplinary cancer research.

Section VII. Agency Contacts

The following contacts have been added:

Scientific/Research Contact(s)

Kara Hall, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6831

Todd Horowitz, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-678-5986

Dan Xi, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6143

Financial/Grants Management Contact(s)

Crystal Wolfrey
National Cancer Institute (NCI)
Telephone: 240-276-6277

All other aspects of this FOA remain unchanged.


Please direct all inquiries to:

Kara Hall, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6831