Notice of Intent to Publish a Funding Opportunity Announcement for Enabling Biomimetic Tissue-Engineered Technologies for Integrative Cancer Research (U01)

Notice Number: NOT-CA-15-026

Key Dates
Release Date:   August 14, 2015
Estimated Publication Date of Announcement:  Winter 2015 
First Estimated Application Due Date:  March 2016 
Earliest Estimated Award Date:  December 2016 
Earliest Estimated Start Date:  December 2016 

Related Announcements

Issued by
National Cancer Institute (NCI)


The National Cancer Institute intends to publish a Funding Opportunity Announcement (FOA) to support the Cancer Tissue Engineering Collaborative (TEC) Research Program. The FOA will invite cooperative agreement research project (U01) applications aimed at the development and characterization of state-of-the-art biomimetic tissue-engineered technologies for understanding cancer biology, prevention, early detection, diagnosis and treatment. The Cancer TEC Research Program will spur collaborative, multidisciplinary projects that engage the fields of regenerative medicine, tissue engineering, and biomaterials with cancer biology. The Program will (1) catalyze the advancement of innovative, well-characterized in vitro and ex vivo systems available for cancer research, (2) expand the breadth of these systems to several cancer types, and (3) promote the exploration of cancer phenomena with biomimetic tissue-engineered systems.  The Program will also allow for sharing of data, resources, and methods for characterization of tissue-engineered technologies with the cancer research community.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Winter 2015 with an expected application due date in March 2016.

This FOA will utilize the U01 (Research Project - Cooperative Agreements) activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators and teams with blends of disciplines that are required to achieve the overall goals of the project to begin to consider applying for this new FOA supporting the Cancer TEC Research Program.

Studies supported by this new FOA will be aimed at developing and characterizing in vitro systems using biomimetic tissue-engineered technologies targeted to address a specific cancer research question. The proposed biomimetic technologies may be new or use innovative methods to leverage existing technologies. Critical to each research project will be validating the biological relevance of the in vitro system. It is expected that projects will take an inventive and engineering approach to define the critical features and parameters for the proposed system, how they are sufficient to mimic the physiology and pathology of the specific cancer question under study, and what characterization will be needed to validate the biological relevance of the system. 



Please direct all inquiries to:

Nastaran Z. Kuhn
National Cancer Institute (NCI)
Telephone: 240-276-6333