Administrative Supplements to Promote Research Collaborations between Hepatocellular Carcinoma Research Laboratories and AIDS Laboratories

Notice Number:  NOT-CA-11-015

Key Dates

Release Date:  June 29, 2011
Receipt Date:  July 30, 2011 
Earliest Anticipated Start Date: September 1, 2011 

Issued by

National Cancer Institute (NCI)


The National Cancer Institute (NCI) announces the availability of funds in Fiscal Year 2011 for administrative supplements to ongoing NCI-funded research projects on hepatocellular carcinoma (HCC). This initiative is designed to stimulate collaborative research between NCI-funded HCC investigators and HIV/AIDS researchers. This initiative is also referred to as the Activities to Promote Research Collaborations between Hepatocellular Carcinoma Research Laboratories and AIDS Laboratories (APRC- HCC and AIDS). 

Important Note: For the complete description of the program, the requirements for request preparation and submission as well as selection factors, all prospective applicants must read the detailed Guidelines for the NCI APRC-HCC and AIDS supplement program available at (

In addition, before submitting a request, interested researchers are strongly encouraged to call their NCI Program Director to verify whether the “parent” grant and the anticipated new collaborations meet the eligibility criteria for these supplements.


The scientific focus of the requests for supplemental funding under this Notice must be on HCC in the context of HIV infection. In addition, the proposed research must meet the criteria of HIV/AIDS research as defined in the FY2011 Trans-NIH Plan (found at

It is expected that collaborations proposed will be for meaningful efforts that would allow the participants to explore emerging and important directions of HCC research in the context of AIDS.


IMPORTANT:  The research proposed by the NIH grantee in the administrative supplement request must be within the original scope of the NIH-supported grant project.  The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives as long as they are within the original scope of the project.  Any cost increases need to result from making modifications to the project in order to take advantage of opportunities that would increase the value of the project consistent with its originally approved objectives and purposes.

Budget and Funding Information

A total of $500,000 is anticipated to be available in Fiscal Year 2011 for these Administrative Supplements.

Individual requests for supplements must not exceed the following limits. For requests proposing one to three collaborations, the maximum total direct costs allowed is $45,000 per year per collaborating "unit" (i.e., the PD/PI on an eligible NCI-funded HCC grant proposing one qualifying collaboration with HIV/AIDS researcher/laboratory may request $45,000 per year). For requests proposing three or more qualifying collaborations (expected to be rare but allowed), the combined requested direct costs must not exceed $135,000 per year.

Provided that the parent grant remains active, requests for supplemental funding may be for periods of up to 2 years (although requests for 1 year or shorter periods are also appropriate).

Submitting an Administrative Supplement Request

Requests for these administrative supplements must be prepared following detailed instructions regarding format and content in the NCI APRC-HCC and AIDS Program Guidelines (

This Notice is a one-time announcement and formal requests must be received on or before July 30, 2011.  Applications must be signed by the Authorized Organizational Representative (AOR) at the grantee institution.

Applicants are strongly encouraged to submit requests electronically as an e-mail attachment in PDF format; however, the signature of the AOR must be clearly visible.  The e-mail address for electronic submission is:

Applicants may also submit applications in paper format (original and one copy) to:

C/o Stephen White, APRC HCC and HIV Program Manager
National Cancer Institute, NIH
6130 Executive Boulevard, EPN Room 5048
Bethesda, MD 20892-7150 (for U.S. Postal Service regular or express mail)
Rockville, MD 20852 (for non-U.S.P.S. delivery)
Telephone: 301-496-5307

Note that the NIH Center for Scientific Review (CSR) IS NOT involved in receipt and processing of these requests.


Inquiries and discussion of plans for responding to this Notice are strongly encouraged.

Direct program/scientific related questions or inquiries to the NCI Program Director servicing the parent grant or to:

Dr. Betsy Read-Connole
NCI APRC HCC and HIV Program Director
Division of Cancer Biology
National Cancer Institute, NIH
Telephone: 301-496-9740

Direct all financial and grants management-related questions or inquiries to:

Joy Kearse
Grants Management Specialist
Office of Grants Administration
National Cancer Institute, NIH
Telephone: 301-846-1010
E-mail: kearsej@mail.nih

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.