NEW NCI POLICY ON LARGE R01 s RELEASE DATE: February 10, 2004 NOTICE: NOT-CA-04-004 National Cancer Institute (NCI) ( NCI is seeing a marked increase in the number of unsolicited RO1 applications submitted with direct cost requests in excess of $700,000 in any single year. Unfortunately, this increase is occurring at a time when the budget is no longer doubling. Since some of these applications are reviewed by the Center for Scientific Review (CSR) and percentiled, it raises the possibility that unanticipated demands will be placed on NCI resources. Such a situation occurred in 2001, when a large number of applications with budgets in excess of $1 million were assigned to NCI and received fundable scores. In order to fund those grants, NCI was forced to apply large administrative reductions to all funded RO1 grants. To allow the NCI to optimally manage its resources and to ensure that all areas of the cancer research continuum are appropriately supported, a new funding policy is being implemented in FY 2004. The new policy states that: A separate payline will be established at each round for unsolicited R01 grants with direct costs in excess of $700,000 for any one year ( large R01’s ). Every effort will be made to maintain the large R01 payline as close as possible to the general R01 payline. However, the large RO1 payline will be determined at each round, taking into consideration scientific scope, scientific merit, and budgetary constraints. Large RO1’s submitted in response to RFAs or PARs, which are not reviewed by CSR, are currently not percentiled and are not affected by this policy. Non-percentiled R01s have been selected for funding on a case-by-case basis for several years. This policy does not supercede or in any way change the NIH policy on The Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs ( which requires advanced approval of applications requesting in excess of $500,000 direct cost in any year. Formal advanced approval to submit an application in excess of $500,000 is still required. This policy relates to the method the NCI will use to select large R01s for funding after peer review has been completed. INQUIRIES: Inquires regarding this notice may be directed to: Referral Officer National Cancer Institute Division of Extramural Activities 6116 Executive Blvd., Room 8041, MSC 8329 Bethesda, MD 20892-8329 Rockville, MD 20852 (for express/courier service) Telephone: 301-496-3428 Fax: 301-402-0275 E-Mail:

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

NIH Office of Extramural Research Logo
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy
NIH... Turning Discovery Into Health®

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.