National Center for Complementary and Integrative Health (NCCIH)
The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for an Open-Access Repository and Database for Anatomical and Physiological Ontology of Acupoints. This initiative will support the development and maintenance of a searchable, open-access database and repository for commonly used acupoints, along with key anatomical and physiological correlates as well as other relevant parameters suitable for human subjects and appropriate animal models. This FOA will utilize a cooperative agreement funding mechanism, U24, to support the development and maintenance of the database and repository, which will serve the research community. The intent is to create a database and repository of high-quality research data that will support rigorous research in the acupuncture field, continue and advance the creation of evidence-based clinical practices, and support sharing of information regarding acupuncture-based interventions and therapies. We believe this database and repository will be transformative for the acupuncture research field as it will offer researchers a rich scientific resource that will bridge and unify research approaches via common concepts, terminology, and parameters, which will lead to more meaningful mechanistic and clinical research results. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications.
The Open-Access Repository and Database must:
• be developed and maintained by leading experts of the acupuncture research community partnering with acupuncture or peripheral nerve stimulation organizations, in collaboration with the NIH;
• serve the acupuncture research community, including both basic research and mechanistic clinical research by having standardized language and common data elements;
• develop high-quality data and support bidirectional translational research;
• be open-access and searchable, including notifications/update/alert systems;
• be capable of storing, organizing, managing, and tracking access to data and resources.
• be compatible with other relevant NIH Databases such as SPARC and BRAIN;
• support annotation of safety issues and confounding factors and practitioner utility.
This database and repository development should include four stages:
1) Development of Acupoint Ontology using both the Eastern and Western nomenclature systems of acupoints;
2) Development of Acupoint Atlas and Repository entering acupuncture point locations into processed imaging dataset;
3) Connection of existing physiological databases to the developed Acupoint Repository; and
4) Design and development of integrative database system for data search, analysis, and retrieval system (including Ontology Query, data mining, Reports, etc.)
Completion of these four stages should be milestone-driven over five years. Suggested timeline of milestones and deliverables must include, but not restricted to, the followings:
Year 1 and 2:
Year 3 to Year 5: Integrating the Acupoint Atlas and Repository with existing physiological databases
NCCIH intends to commit an estimated total cost up to $1,200,000 per year for five years
Set-aside fund for this FOA is up to $1,200,000 per year for 5 years to support one award
Applications are not being solicited at this time.
Please direct all inquiries to:
Emrin Horgusluoglu, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)/ Basic and Mechanistic Branch