Notice of Intent to Publish a Funding Opportunity Announcement for NIH Health Care Systems Research Collaboratory - Pragmatic and Implementation Trials of Embedded Interventions (UG3/UH3 Clinical Trials Optional)
Notice Number:

Key Dates

Release Date:
August 25, 2021
Estimated Publication Date of Funding Opportunity Announcement:
September 15, 2021
First Estimated Application Due Date:
November 15, 2021
Earliest Estimated Award Date:
July 01, 2022
Earliest Estimated Start Date:
July 01, 2022
Related Announcements


Issued by

National Center for Complementary and Integrative Health (NCCIH)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Aging (NIA)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)


The National Center for Complementary and Integrative Health (NCCIH), with other NIH Institutes, Centers, and Offices (ICOs), intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for phased cooperative research applications to conduct efficient, large-scale embedded pragmatic or implementation trials within health care systems. Research focused on improving health outcomes in Americans across the lifespan and addressing health disparities in populations who experience higher rates of certain diseases and higher mortality compared with the general population will be a high priority. Results from the pragmatic or implementation trials supported by this FOA should inform policy makers, payers, health care providers and patients across diverse patient care settings. Awards made under this FOA will initially support a one-year milestone-driven planning phase (UG3), with possible transition to a performance phase (UH3). UG3 projects that have met the scientific milestone and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The FOA is expected to be published in Summer 2021 with an expected application due date in Fall 2021.

This FOA will utilize the UG3/UH3 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise and insights into this area of pragmatic or implementation trials embedded in health care systems to begin to consider applying for this new FOA.

In addition, collaborative investigations combining expertise in pragmatic or implementation trials and interventions to reduce or eliminate health disparities in specific health populations will be encouraged, and these investigators should also begin considering applying under the new FOA.

Among the areas of research encouraged in this initiative are trials that will evaluate the effectiveness of or study strategies used to effectively, equitably, and efficiently implement evidence-based interventions and/or guidelines. This FOA will require that the intervention under study be embedded into health care delivery systems, “real world” settings. Studies can propose to integrate multi-componentor multiple interventions that have demonstrated efficacy into HCS; or implement HCS changes to improve adherence to evidence-based guidelines. Trials should be conducted across three or more health care systems (HCS) that provide care to generalizable patient populations, and it is encouraged that investigators include populations experiencing health disparities. All trials will become part of and work with the NIH HCS Research Collaboratory program and have access to the expertise of the HCS Collaboratory Coordinating Center. Each participating Institute, Center and Office (ICO) will identify high priority research areas for this FOA.

Funding Information
Estimated Total Funding

NCCIH, up to $1,000,000 direct costs

NIA, up to $1,000,000 direct costs

NHLBI, up to $500,000 direct costs

NIAMS, up to $500,000 direct cost

NIMHD, up to $500,000 direct costs

NINR, up to $500,000 direct costs

Expected Number of Awards


Estimated Award Ceiling

The application budget for the one-year UG3 phase is limited to $500,000 in direct costs. Costs for each year of the UH3 phase are limited to $1 million in direct costs. The maximum period of funding for the UG3 phase is one year and the maximum period of funding of the UH3 phase is four years, for a total of five years for the entire UG3/UH3 award.

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Wendy Weber, N.D., Ph.D., M.P.H.

National Center for Complementary and Integrative Health (NCCIH)


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices