Notice of Intent to Publish a Funding Opportunity Announcement for NMR Open Access Data Exchange (U24, Clinical Trial Not Allowed)

Notice Number: NOT-AT-19-003

Key Dates

Release Date:October 09, 2018
Estimated Publication Date of Funding Opportunity Announcement: November 15, 2018
First Estimated Application Due Date: April 18, 2019
Earliest Estimated Award Date: July 01, 2020
Earliest Estimated Start Date: July 01, 2020

Related Announcements

Issued by
National Center for Complementary and Integrative Health (NCCIH)
Office of Dietary Supplements (ODS)


The National Center for Complementary and Integrative Health (NCCIH) with the Office of Dietary Supplements (ODS) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for development of an NMR Open Data Exchange (NP-NODE) and associated efforts to accelerate coordination and data sharing among natural products researchers more broadly. The NP-NODE will create the resources necessary to facilitate the upload, download, storage, search and analysis of raw NMR data. This resource will comply with FAIR data principles. These principles have been widely accepted and are based on the agreement that scientific data should be Findable, Accessible, Interoperable, and Reusable (FAIR). Ultimately, this resource will provide natural products researchers the power to mine NMR data in a way that is currently not possible. In parallel, it will develop an outreach plan to obtain input from diverse communities of researchers to develop consensus on the format and most critical features of the repository. More broadly, the FOA supports and requires the coordination across the natural products research community to facilitate development of standards to accelerate sharing of data relevant to natural product chemistry and biology.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in Fall 2018 with an expected application due date in Spring 2019.

This FOA will utilize the U24 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This FOA is being released in conjunction with the Center for Natural Product Technology, Methodology and Productivity Optimization, and the Botanical Dietary Supplement Research Centers Program. Collectively, the awards under these FOAs constitute the NIH Consortium for Advancing Research on Botanical and Other Natural Products (CARBON) Program. Applicants applying under this NP-NODE FOA are encouraged to collaborate, where appropriate, with the NP-TEMPO, the Botanical Dietary Supplement Research Centers, and other NCCIH, ODS, and NIH supported grantees.

The NP-NODE is expected to establish a data repository for sharing of raw NMR data. Ultimately, the NP-NODE aims to establish a powerful resource that will house the majority of the world’s natural products NMR data in a format that allows facile cross-linking with other data repositories with associated tools that permit the rapid interrogation of NMR spectra across the repository. To accomplish this the grantee will need to establish the platform for the repository and collaborate widely with the natural products community to develop consensus on the raw data format and minimum data standards for the repository. Additionally, the grantee is expected to actively solicit through various channels deposition of data to populate the repository. Importantly, the grantee will also need to develop a plan for how deposited data is to be curated. The NP-NODE should also include basic tools to facilitate search and comparison of spectral data and associated structures while also allowing for other groups to develop additional tools using the deposited data. The database must be structured and annotated in such a way as to allow and support linking with other data repositories that contain orthogonal data on the same compounds.

Importantly, the NMR data repository is the cornerstone of what is expected to be a larger effort which seeks to raise standards for the natural products research community. For the purposes of this FOA, natural products include vitamins, minerals, and probiotics as well as small molecules derived from plants, fungi, bacteria, marine organisms or animals. They may also exist along a spectrum of complexity from crude extracts to purified constituents. The NP-NODE will also coordinate broadly with the natural products research community to establish good research practices related to reporting and sharing of all natural products related research data. The conversation should build understanding of, and agreement on, the importance of abiding by the FAIR data principles.

Lastly, NCCIH will utilize the NP-NODE to help enforce the principles of the NCCIH Product Integrity Policy. This policy establishes standards regarding the quality control data expected of any natural

product to be used in an NCCIH funded grant. It is expected that the NP-NODE will collaborate with NCCIH and prospective NCCIH grantees to evaluate data submitted in response to this policy. This will include recommendations about additional pieces of data that would help fully address the requirements of the policy as well as potential collaborators in the form of companies, contract labs, or academic groups that could help acquire that information. Importantly, the NP-NODE is not expected to provide that data directly except in special cases. Furthermore, it is not expected that the NP-NODE will have expertise on hand to directly address the full range of products that are within the purview of NCCIH. Rather, the NP-NODE will serve an advisory function to assist prospective NCCIH grantees in satisfying the requirements of the policy.

The NP-NODE is expected to include, but is not limited to, the following activities:

  • Development of new or selection of existing platform to house raw NMR data;
  • Development of a user-friendly interface to allow for upload, download, search and analysis of NMR data in the repository;
  • Creation of tools and standards to facilitate widespread utilization of the repository;
  • Encouragement of additional tools from the natural products research community that leverage the repository data
  • Broad coordination across the natural products research community to establish minimum information standards for natural products research beyond NMR data; that are consistent with existing standards, such as herbal CONSORT, ARRIVE, etc.

Funding Information

Estimated Total Funding Up to $1,000,000
Expected Number of Awards 1
Estimated Award Ceiling Application budgets are limited to $600K in Direct Costs but need to reflect the actual needs of the proposed project
Primary CFDA Numbers93.213, 93.321

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization

Applications are not being solicited at this time.


Please direct all inquiries to:

D. Craig Hopp, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)

Barbara C. Sorkin, Ph.D.
Office of Dietary Supplements (ODS)
Telephone: 301-435-3605