Notice Number: NOT-AT-17-007

Key Dates
Release Date: April 19, 2017

Issued by
National Center for Complementary and Integrative Health (NCCIH)

Purpose

The purpose of this notice is to announce a change in the types of Mind and Body Interventions that will be supported by the Funding Opportunity Announcement PAR-17-149 , "Phased Innovation Award for Mechanistic Studies to Optimize Mind and Body Interventions in NCCIH High Priority Research Topics (R61/R33)". Specifically, PAR-17-149 now accepts applications studying complex interventions such as music or art approaches.

Funding Opportunity Purpose in PAR-17-162

Currently reads as:

Understanding the mechanisms by which complementary or integrative Mind and Body Interventions exert their clinical effects is critical for the development of optimized interventions that target specific conditions and disorders.

The purpose of this funding opportunity announcement (FOA) is to establish a phased research approach to investigate and optimize the mechanisms underlying Mind and Body Interventions. This FOA will support two-phased research applications. The first phase, funded by the R61 mechanism, will provide funding for up to two years to investigate the biological, neurological, physiological, and/or mechanisms or behavioral processes underlying a Mind and Body Intervention (e.g., meditation, spinal manipulation, massage, yoga, tai chi, hypnosis, or acupuncture). The second phase, funded under the R33 mechanism, will provide up to three years of support to: (1) optimize the mechanisms or processes identified in the R61 phase through further modifications to the intervention, (2) study the integration of approaches that may affect the same underlying mechanisms or processes, or (3) further study the relationship between the intervention and the underlying mechanism of action with a relevant target population. This second R33 phase should also aim to provide preliminary evidence that the mechanisms or processes modulated by the interventions are associated with functional outcomes or clinical benefits for specific conditions or disorders. Subject to the availability of funds, transition from the R61 to the R33 phase of the award will be administratively reviewed and will be determined by successful completion of Go/No-Go Criteria that need to be clearly specified in the R61 phase application. This FOA is not appropriate for clinical trials with the primary objectives to determine efficacy or effectiveness of clinical outcomes.
Modified to read as:

Understanding the mechanisms by which complementary or integrative Mind and Body Interventions exert their clinical effects is critical for the development of optimized interventions that target specific conditions and disorders.

The purpose of this funding opportunity announcement (FOA) is to establish a phased research approach to investigate and optimize the mechanisms underlying Mind and Body Interventions. This FOA will support two-phased research applications. The first phase, funded by the R61 mechanism, will provide funding for up to two years to investigate the biological, neurological, physiological, and/or mechanisms or behavioral processes underlying a Mind and Body Intervention (e.g., meditation, spinal manipulation, massage, yoga, tai chi, hypnosis, acupuncture, music or art approaches). The second phase, funded under the R33 mechanism, will provide up to three years of support to: (1) optimize the mechanisms or processes identified in the R61 phase through further modifications to the intervention, (2) study the integration of approaches that may affect the same underlying mechanisms or processes, or (3) further study the relationship between the intervention and the underlying mechanism of action with a relevant target population. This second R33 phase should also aim to provide preliminary evidence that the mechanisms or processes modulated by the interventions are associated with functional outcomes or clinical benefits for specific conditions or disorders. Subject to the availability of funds, transition from the R61 to the R33 phase of the award will be administratively reviewed and will be determined by successful completion of Go/No-Go Criteria that need to be clearly specified in the R61 phase application. This FOA is not appropriate for clinical trials with the primary objectives to determine efficacy or effectiveness of clinical outcomes.

Background in PAR-17-162

Currently reads as:

The National Center for Complementary and Integrative Health (NCCIH) is committed to the rigorous investigation of Mind and Body Interventions to determine their safety and usefulness. For the purposes of this FOA, Mind and Body Interventions are non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), meditative movement approaches (e.g., yoga, tai-chi, qigong), or some combination of these approaches. More about the current Mind and Body Interventions supported by the NCCIH may be found at http://nccih.nih.gov/health/integrative-health.

Modified to read as:

The National Center for Complementary and Integrative Health (NCCIH) is committed to the rigorous investigation of Mind and Body Interventions to determine their safety and usefulness. For the purposes of this FOA, Mind and Body Interventions are non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), meditative movement approaches (e.g., yoga, tai-chi, qigong), some combination of these approaches, as well as complex interventions (e.g., music or art approaches). More about the current Mind and Body Interventions supported by the NCCIH may be found at http://nccih.nih.gov/health/integrative-health.

All other aspects of this FOA remain unchanged.

Inquiries

Please direct all inquiries to:

Wen G. Chen, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-451-3989
Email: chenw@mail.nih.gov