Notice of NIAMS-specific language in RFA-NR-25-003 “Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)”
Notice Number:
NOT-AR-25-013

Key Dates

Release Date:

January 21, 2025

Related Announcements

  • December 11, 2024 -  Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)". See NOFO RFA-NR-25-003.

Issued by

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Purpose

The purpose of this Notice is to add NIAMS-specific language in RFA-NR-25-003 “Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)”. The following updates have been made to RFA-NR-25-003 (shown in bold italics) to reflect NIAMS' participation in this NOFO.

The following section of RFA-NR-25-003 has been revised:

Part 2. Section I. Notice of Funding Opportunity Description

Areas of Interest of Participating Institutes, Centers, and Offices (ICOs)

National Institute of Environmental Health Sciences (NIEHS)

NIEHS’ mission is to discover how the environment affects people in order to promote healthier lives and has long worked to reduce environmental health disparities and promote environmental justice. NIEHS is interested in innovative intervention research that addresses the interaction of SDOH with chemical and other environmental exposures that compromise health and contribute to health disparities.  Examples of environmental exposures which are considered of primary interest for NIEHS include but are not limited to: industrial chemicals or manufacturing byproducts, metals, pesticides, herbicides, air pollutants and other inhaled toxicants, particulates, or fibers, fungal, and bacterial or biologically derived toxins. Applicants are strongly encouraged to reach out to the Scientific Contact in the NOFO to discuss if the application fits the NIEHS mission. Applications responsive to NIEHS are required to clearly identify the environmental exposure(s) of interest and describe the intersection of the exposure(s) with SDOH.  The use of a conceptual model demonstrating the relationship of SDOH with the environmental exposure(s) of interest is highly encouraged. While the Transformative Research to Address Health Disparities and Advance Health Equity initiative supports the evaluation of existing or upcoming interventions, NIEHS is particularly interested in: 1) prospective interventions that develop and test interventions addressing the intersection of social and environmental determinants of health at multiple levels and 2) implementation research (including hybrid effectiveness-implementation studies) focused on strategies to adopt and integrate evidence-based interventions that eliminate environmental health disparities and advance environmental health equity. For applications proposing prospective interventions and implementation research, the use of implementation science frameworks is strongly suggested to promote acceptability, scalability, and sustainability.

Office of Disease Prevention (ODP)

The ODP is the lead office at the NIH responsible for assessing, facilitating, and stimulating research in disease prevention. In partnership with the 27 NIH Institutes and Centers, the ODP strives to increase the scope, quality, dissemination, and impact of NIH-supported prevention research. The ODP is interested in providing co-funding support for research that has strong implications for disease and injury prevention and health equity and that include innovative and appropriate research design, measurement, and analysis methods. For this RFA, ODP is interested in multi-site and/or multi-sectoral interventions that address common risk factors for morbidity and mortality among populations that experience health disparities, including tobacco use, overweight/obesity, poor diet, physical inactivity, alcohol misuse, drug misuse, risky sexual behavior, injury and violence, infectious disease, and environmental health. For additional information about ODP’s research priorities and interests, please refer to the ODP Strategic Plan for Fiscal Years 2024–2028.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases. Research areas include rheumatology, orthopaedics, dermatology, metabolic bone diseases, heritable disorders of bone and cartilage, inherited and inflammatory muscle diseases, and sports and rehabilitation medicine. In the context of this NOFO, the NIAMS is particularly interested in innovative intervention research that integrates biomedical and behavioral mechanisms, on both individual and community levels, to reduce and encourage elimination of health disparities for patients with multiple chronic conditions within the NIAMS mission relevant diseases, such as osteoarthritis (for specifics, please visit the website of the Health Disparities in Osteoarthritis Workshop) or systemic lupus erythematosus (SLE). NIAMS will not accept to this NOFO a clinical trial application that proposes to test a clinical outcome as its primary objective, but will accept clinical trial applications proposing mechanistic studies as defined in NOT-AR-21-009. Applicants are encouraged to discuss potential applications with the appropriate NIAMS program director.

 All other aspects of this NOFO remain unchanged.

Inquiries

Please direct all inquiries to:

Xincheng Zheng (Ted), Ph.D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Phone: 301-594-4953
E-mail: [email protected]